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VLVbio‘s product series PEVIVA specialises in ELISA assays for the quantification of the Cell Death modes apoptosis and necrosis. Our products are used for research and clinical trials in the fields of oncology and hepatology.
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The PEVIVA product series is specialised in production and development of high end in vitro and in vivo biomarkers and antibodies. The PEVIVA products specializes in ELISA assays for the quantification of Cell Death modes, such as apoptosis and necrosis.
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M30 Apoptosense® ELISA is a unique tool for reliable and reproducible quantitative detection of apoptosis of keratin 18 (K18) positive cells. The assay is intended for patient sera. Another useful application is the detection of tumor apoptosis in mouse xenograft models using plasma samples. M30 Apoptosense® is an ELISA assay based on the M30 monoclonal antibody.
The M65® ELISA measures soluble keratin 18 (K18) released from dying cells and can be used to assess overall cell death (due to apoptosis and necrosis) of epithelial cells. The M65® ELISA is primarily intended to be used together with the M30 Apoptosense® assay, which specifically measures apoptosis. The M65® ELISA assay is registered as a medical device for in vitro diagnostic use in accordance with the CE-IVD directive.
The M30 CytoDeath™ ELISA is a powerful drug screening tool. It is useful for in vitro characterization of apoptosis-inducing drugs, including establishment of time course kinetics and dose-response relationships. The effects of large numbers of siRNAs on apoptosis can be tested in the 96 well format. The assay offers a unique possibility to quantify apoptosis of epithelially derived cells in multicellular spheroids and organ culture systems.