M30-Apoptosense® ELISA References
Original Papers
M30‑Apoptosense® assay:Hägg, M., Bivén, K., Ueno, T., Rydlander, L, Björklund, P., Wiman, K.G., Shoshan, M.C. and Linder, S. (2002)
A novel high‑through‑put assay for screening of pro‑apoptotic drugs.
Invest. New Drugs, 20: 253‑259.
»Abstract
M30‑antibody:
Leers, M.P., Kölgen, W., Björklund, V., Bergman, T., Tribbick, G., Persson, B., Björklund, P., Ramaekers, F.C.S., Björklund, B., Nap, M., Jörnvall, H., and Schutte, B. (1999).
Immunocytochemical detection and mapping of a Cytokeratin 18 neo‑epitope exposed during early apoptosis.
J Pathol 187, 567‑572.
»Abstract
REFERENCES IN CHRONOLOGICAL ORDER |
(Updated on June 3, 2010) |
Valva P, De Matteo E, Galoppo MC, Gismondi MI , Preciado MV. (2010)
Apoptosis markers related to pathogenesis of pediatric chronic hepatitis C virus infection: M30 mirrors the severity of steatosis.
J Med Virol. 82(6):949-57.
»Abstract
Bechmann LP, Gieseler RK, Sowa JP, Kahraman A, Erhard J, Wedemeyer I, Emons B, Jochum C, Feldkamp T, Gerken G, Canbay A. (2010)
Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis.
Liver Int. 2010 Apr 9. [Epub ahead of print]
»Abstract
Yaman E, Coskun U, Sancak B, Buyukberber S, Ozturk B, Benekli M. (2010) Serum M30 levels are associated with survival in advanced gastric carcinoma patients.
Int Immunopharmacol. 2010 Mar 31
»Abstract
Tsutsui M, Tanaka N, Kawakubo M, Sheena Y, Horiuchi A, Komatsu M,, Nagaya T, Joshita S, Yoshizawa K, Aoyama T, Tanaka E, Sano K. (2010)
Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels.
J Clin Gastroenter e-pub Jan 25
»Abstract
Papatheodoridis GV, Hadziyannis E, Tsochatzis E, Georgiou A, Kafiri G, Tiniakos DG, Margariti K, Archimandritis AJ. (2010)
Serum apoptotic caspase activity in chronic hepatitis C and nonalcoholic Fatty liver disease.
J Clin Gastroenter 44: 87-95.
»Abstract
Linder S, Olofsson MH, Herrmann R, Ulukaya E. (2010)
Utilization of cytokeratin-based biomarkers for pharmacodynamic studies.
Exp Rev Mol Diagn 10: 353-9.
»Abstract
Dive C, Smith RA, Garner E, Ward T, George-Smith SS, Campbell F, Greenhalf W, Ghaneh P, Neoptolemos JP. (2010)
Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer.
Br J Cancer 102:577-82.
»Abstract
Kahraman A, Schlattjan M, Kocabayoglu P, Yildiz-Meziletoglu S, Schlensak M, Fingas CD, Wedemeyer I, Marquitan G, Gieseler RK, Baba HA, Gerken G, Canbay A. (2010)
Major histocompatibility complex class I-related chains A and B (MIC A/B): a novel role in nonalcoholic steatohepatitis.
Hepatology 51, 92-102.
»Abstract
Tan S, Bechmann LP, Benson S, Dietz T, Eichner S, Hahn S, Janssen OE, Lahner H, Gerken G, Mann K, Canbay A. (2010)
Apoptotic markers indicate nonalcoholic steatohepatitis in polycystic ovary syndrome.
J Clin Endocrinol Metab. 95:343-8.
»Abstract
Civera M, Urios A, Garcia-Torres ML, Ortega J, Martinez-Valls J, Cassinello N, Del Olmo JA, Ferrandez A, Rodrigo JM, Montoliu C. (2010)
Relationship between insulin resistance, inflammation and liver cell apoptosis in patients with severe obesity.
Diabetes Metab Res Rev. 2010 Mar 10.
»Abstract
Sgier C, Müllhaupt B, Gerlach T, Moradpour D, Negro F, Malé PJ, Heim MH, Malinverni R, Cerny A, Dufour JF. (2010)
Effect of antiviral therapy on circulating cytokeratin-18 fragments in patients with chronic hepatitis C.
J Viral Hepat. 2010 Jan 13.
»Abstract
Ulukaya S, Ulukaya E, Alper I, Yilmaztepe-Oral A, Kilic M. (2009)
Soluble cytokeratin 18 biomarkers may provide information on the type of cell death during early ischemia and reperfusion periods of liver transplantation.
Clin Transplant. 2009 Dec 18.
»Abstract
Ausch C, Buxhofer-Ausch V, Olszewski U, Schiessel R, Ogris E, Hinterberger W, Hamilton G. (2009)
Circulating Cytokeratin 18 Fragment M65-A Potential Marker of Malignancy in Colorectal Cancer Patients.
J Gastrointest Surg. 2009 Sep 2.
»Abstract
Ausch C, Buxhofer-Ausch V, Olszewski U, Hinterberger W, Ogris E, Schiessel R, Hamilton G. (2009)
Caspase-cleaved cytokeratin 18 fragment (M30) as marker of postoperative residual tumor load in colon cancer patients.
Eur J Surg Oncol. 2009 Nov;35(11):1164-8.
»Abstract
Balmer ML, Siegrist K, Zimmermann A, Dufour JF. (2009)
Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis.
Liver Int. 2009 Apr 17
»Abstract
Bantel H, Schulze-Osthoff K. (2009)
Cell death in sepsis: a matter of how, when, and where.
Crit Care. 2009;13(4):173.
»Abstract
Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, Mankin H, Hornicek FJ. (2009)
Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines
Mol Cancer Ther. 2009 Aug;8(8):2122-30.
»Abstract
Fayad W, Fryknäs M, Brnjic S, Olofsson MH, Larsson R, Linder S. (2009)
Identification of a Novel Topoisomerase Inhibitor Effective in Cells Overexpressing Drug Efflux Transporters.
PLoS ONE 4(10): e7238.
»Abstract
Fayad W, Brnjic S, Berglind D, Blixt S, Shoshan MC, Berndtsson M, Olofsson MH, Linder S. (2009)
Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model.
Int J Cancer 15: 2450-5.
»Abstract
Feldstein A, Wieckowska A, Lopez AR, Liu YC, Zein NN, McCullough AJ. (2009)
Cytokeratin-18 fragment levels as noninvasive biomarker for nonalcoholic steatohepatitis: A multicenter validation study.
Hepatology, Volume: Vol. 50, No. 7, 2009
»Abstract
To the editor:
Yilmaz Y (2009)
Defragmenting the noninvasive diagnosis of nonalcoholic steatohepatitis: Hopes from cytokeratin-18.
Hepatology, Volume 50 Issue 3, Page 990
»Abstract
Hacker S, Lambers C, Pollreisz A, Hoetzenecker K, Lichtenauer M, Mangold A, Niederpold T, Hacker A, Lang G, Dworschak M, Vukovich T, Gerner C, Klepetko W, Ankersmit HJ. (2009)
Increased soluble serum markers caspase-cleaved cytokeratin-18, histones, and ST2 indicate apoptotic turnover and chronic immune response in COPD.
J Clin Lab Anal. 23:372-9.
»Abstract
To the editor:
Bantel H, Bahr MJ, Schulze-Osthoff K. (2009)
An apoptosis biomarker for prediction of nonalcoholic steatohepatitis.
Hepatology, Volume 50 Issue 3, Page 991
»Abstract
Feldstein A, Kleiner D, Kravetz D, Buck M. (2009)
Severe hepatocellular injury with apoptosis induced by a hepatitis C polymerase inhibitor.
J Clin Gastroenterol. 2009 Apr;43(4):374-81.
»Abstract
Fisher MB, Zhang XQ, McConkey DJ, Benedict WF. (2009)
Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon alpha: possible use as a surrogate marker.
Cancer Gene Ther. 2009 Jul;16(7):567-72.
»Abstract
Hamad RR, Bremme K, Kallner A, Sten-Linder M. (2009)
Increased levels of an apoptotic product in the sera from women with pre-eclampsia.
Scand J Clin Lab Invest. 2009;69(2):204-8.
»Abstract
Hashimoto E, Farrell GC. (2009)
Will non-invasive markers replace liver biopsy for diagnosing and staging fibrosis in non-alcoholic steatohepatitis?
J Gastroenterol Hepatol. 2009 Apr;24(4):501-3.
»Abstract and article
Hellberg V, Wallin I, Eriksson S, Hernlund E, Jerremalm E, Berndtsson M, Eksborg S, Arnér ES, Shoshan M, Ehrsson H, Laurell G. (2009)
Cisplatin and oxaliplatin toxicity: importance of cochlear kinetics as a determinant for ototoxicity.
J Natl Cancer Inst. 2009 Jan 7;101(1):37-47.
»Abstract
Hernlund E, Kutuk O, Basaga H, Linder S, Panaretakis T, Shoshan M. (2009)
Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation.
Free Radic Biol Med. 2009 Jun 15;46(12):1607-13.
»Abstract
Hofer S, Brenner T, Bopp C, Steppan J, Lichtenstern C, Weitz J, Bruckner T, Martin E, Hoffmann U and Weigand. (2009)
Cell death serum biomarkers are early predictors for survival in severe septic patients with hepatic dysfunction
Critical Care 2009, 13:R93.
»Abstract and article
Hou JM, Greystoke A, Lancashire L, Cummings J, Ward T, Board R, Amir E, Hughes S, Krebs M, Hughes A, Ranson M, Lorigan P, Dive C, Blackhall FH. (2009)
Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy.
Am J Pathol. 2009 Aug;175(2):808-16.
»Abstract
Jochum C, Gieseler RK, Gawlista I, Fiedler A, Manka P, Saner FH, Roggendorf M, Gerken G, Canbay A. (2009)
Hepatitis B-associated Acute Liver Failure: Immediate Treatment with Entecavir Inhibits Hepatitis B Virus Replication and Potentially Its Sequelae
Digestion. 2009 Oct 15;80(4):235-240.
»Abstract
Kieback DG (2009)
Adenovirus-mediated thymidine kinase gene therapy induces apoptosis in human epithelial ovarian cancer cells and damages PARP-1.
In Vivo. 2009 Jan-Feb;23(1):77-80
»Abstract
Koelink PJ, Lamers CB, Hommes DW, Verspaget HW. (2009)
Circulating cell death products predict clinical outcome of colorectal cancer patients.
BMC Cancer. 2009 Mar 23;9:88.
»Abstract
Koelink PJ, Sier CF, Hommes DW, Lamers CB, Verspaget HW. (2009)
Clinical significance of stromal apoptosis in colorectal cancer.
Br J Cancer. 101:765-73.
»Abstract
Kutuk O, Arisan ED, Tezil T, Shoshan MC, Basaga H. (2009)
Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation.
Carcinogenesis. 2009 Sep;30(9):1517-27.
»Abstract
Linder S, Alaiya A. (2009)
Serum efficacy biomarkers for oncology.
Biomarkers Med. 2009, Vol. 3, No. 1, Pages 47-54
»Abstract
Malik R, Chang M, Bhaskar K, Nasser I, Curry M, Schuppan D, Byrnes V, Afdhal N. (2009)
The clinical utility of biomarkers and the nonalcoholic steatohepatitis CRN liver biopsy scoring system in patients with nonalcoholic fatty liver disease.
J Gastroenterol Hepatol. 2009 Apr;24(4):564-8.
»Abstract
Musso G, Gambino R, Pacini G, Pagano G, Durazzo M, Cassader M. (2009)
Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH.
Hepatology. 2009 Feb;49(2):426-35.
»Abstract
Musso G, Gambino R, Pacini G, De Michieli F, Cassader M. (2009)
Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver.
Am J Clin Nutr. 2009 Feb;89(2):558-67.
»Abstract
Nilsonne G, Olm E, Szulkin A, Mundt F, Stein A, Kocic B, Rundlöf AK, Fernandes AP, Björnstedt M, Dobra K. (2009)
Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure.
Journal of Experimental & Clinical Cancer Research 2009, 28:92
»Abstract
Olofsson MH, Cummings J, Fayad W, Brnjic S, Herrmann R, Berndtsson M, Hodgkinson C, Dean E, Odedra R, Wilkinson RW, Mundt KE, Busk M, Dive C, Linder S. (2009)
Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker.
Cancer Biomark. 2009;5(3):117-25.
»Abstract
Ozturk B, Coskun U, Sancak B, Yaman E, Buyukberber S, Benekli M. (2009)
Elevated serum levels of M30 and M65 in patients with locally advanced head and neck tumors.
Int Immunopharmacol. 2009 May;9(5):645-8.
»Abstract
Pfeifer D, Wallin A, Holmlund B, Sun XF. (2009)
Protein expression following gamma-irradiation relevant to growth arrest and apoptosis in colon cancer cells.
J Cancer Res Clin Oncol. 2009 Nov;135(11):1583-92.
»Abstract
Scott LC, Evans TR, Cassidy J, Harden S, Paul J, Ullah R, O'Brien V, Brown R. (2009)
Cytokeratin 18 in plasma of patients with gastrointestinal adenocarcinoma as a biomarker of tumour response.
Br J Cancer. 2009 Aug 4;101(3):410-7.
»Abstract
Ullen A, Schwarz S, Lennartsson L, Kalkner KM, Sandstrom P, Costa F, Lennernas B, Linder S, Nilsson S. (2009)
Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines.
Scand J Urol Nephrol. 2009;43(2):98-103.
»Abstract
Yilmaz Y (2009)
Systematic review caspase-cleaved fragments of cytokeratin 18 – the promises and challenges of a biomarker for chronic liver disease
Aliment Pharmacol Ther. 2009 Dec 1;30(11-12):1103-9
»Abstract
Yilmaz Y, Kedrah AE, Ozdogan O. (2009)
Cytokeratin-18 fragments and biomarkers of the metabolic syndrome in nonalcoholic steatohepatitis.
World J Gastroenterol. 2009 Sep 21;15(35):4387-91.
»Abstract
Wedemeyer I, Bechmann LP, Odenthal M, Jochum C, Marquitan G, Drebber U, Gerken G, Gieseler RK, Dienes HP, Canbay A. (2009)
Adiponectin inhibits steatotic CD95/Fas up-regulation by hepatocytes: therapeutic implications for hepatitis C.
J Hepatol. 2009 Jan;50(1):140-9.
»Abstract
2008
Beachy SH, Repasky EA. (2008)
Using extracellular biomarkers for monitoring efficacy of therapeutics in cancer patients: an update.
Cancer Immunol Immunother. 2008 Jun;57(6):759‑75.
»Abstract
Bechmann LP., Marquitan G, Jochum C, Saner F, Gerken G, Canbay A (2008)
Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute‑on‑chronic liver failure
Liver International 2008 May;28(5):713‑6
»Abstract
Bem RA, Bos AP, Bots M, Wolbink AM, van Ham SM, Medema JP, Lutter R, van Woensel JB. (2008)
Activation of the Granzyme Pathway in Children with Severe Respiratory Syncytial Virus Infection.
Pediatr Res. 2008 Jun;63(6):650-5.
»Abstract
Carpinelli P, Moll J. (2008)
Aurora kinase inhibitors: identification and preclinical validation of their biomarkers.
Expert Opin Ther Targets. 2008 Jan;12(1):69‑80.
»Abstract
Cummings J, Hodgkinson C, Odedra R, Sini P, Heaton SP, Mundt KE, Ward TH, Wilkinson RW, Growcott J, Hughes A, Dive C. (2008)
Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity.
Mol Cancer Ther. 2008 Mar;7(3):455‑63.
»Abstract
Cummings J, Ward TH, Greystoke A, Ranson M, Dive C. (2008)
Biomarker method validation in anticancer drug development.
Br J Pharmacol. 2008 Feb;153(4):646‑56.
»Abstract
de Haas EC, di Pietro A, Simpson KL, Meijer C, Suurmeijer AJ, Lancashire LJ, Cummings J, de Jong S, de Vries EG, Dive C, Gietema JA. (2008)
Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug‑sensitive tumor, testicular cancer.
Neoplasia. 2008 Oct;10(10):1041‑8.
»Abstract
Diab DL, Yerian L, Schauer P, Kashyap SR, Lopez R, Hazen SL, Feldstein AE. (2008)
Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients.
Clin Gastroenterol Hepatol. 2008 Nov;6(11):1249-54.
»Abstract
Friedman J, Dunn RL, Wood D, Vaishampayan U, Wu A, Bradley D, Montie J, Sarkar FH, Shah RB, Hussain M. (2008)
Neoadjuvant docetaxel and capecitabine in patients with high risk prostate cancer.
J Urol. 2008 Mar;179(3):911‑5; discussion 915‑6.
»Abstract
Greystoke A., Cummings J., Ward T., Simpson K., Renehan A., Butt F., Moore D., Gietema J., Blackhall F., Ranson M., Hughes A., Dive C. (2008)
Optimisation of circulating biomarkers of cell death for routine clinical use.
Ann Oncol. 2008 May;19(5):990-5.
»Abstract
Hernlund E, Ihrlund LS, Khan O, Ates YO, Linder S, Panaretakis T, Shoshan MC (2008)
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir.
Int J Cancer. 2008 Jul 15;123(2):476-83.
»Abstract
Hu Y, Tan R, MacCalman CD, Eastabrook G, Park SH, Dutz JP, von Dadelszen P. (2008)
IFN‑gamma‑mediated extravillous trophoblast outgrowth inhibition in first trimester explant culture: a role for insulin‑like growth factors.
Mol Hum Reprod. 2008 May;14(5):281‑9.
»Abstract
Ihrlund Strandberg L, Hernlund E, Khan O and Shoshan M C. (2008)
3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
Molecular Oncology Volume 2, Issue 1, June 2008, Pages 94-101
»Abstract
Krysko DV, Vanden Berghe T, D'Herde K, Vandenabeele P. (2008)
Apoptosis and necrosis: detection, discrimination and phagocytosis.
Methods. 2008 Mar;44(3):205‑21.
»Abstract
Lee KS, Choi YH, Kim YS, Baik SH, Oh YJ, Sheen SS, Park JH, Hwang SC, Park KJ. (2008)
Evaluation of bronchoalveolar lavage fluid from ARDS patients with regard to apoptosis.
Respir Med. 2008 Mar;102(3):464‑9.
»Abstract
Panaretakis T, Hjortsberg L, Tamm KP, Björklund AC, Joseph B, Grandér D. (2008)
Interferon alpha induces nucleus‑independent apoptosis by activating extracellular signal‑regulated kinase 1/2 and c‑Jun NH2‑terminal kinase downstream of phosphatidylinositol 3‑kinase and mammalian target of rapamycin.
Mol Biol Cell. 2008 Jan;19(1):41‑50.
»Abstract
Papatheodoridis GV, Hadizyannis E, Tsochatzis E, Chrysanthos N, Georgiou A, Kafiri G, Manolakopoulos S, Tiniakos DG, Giannousis I, Manesis E, Archimandritis AJ. (2008)
Serum Apoptotic Caspase Activity As A Marker Of Severity In Hbeag‑Negative Chronic Hepatitis B Virus Infection.
Gut. 2008 Apr;57(4):500‑6.
»Abstract
Simopoulos C, Tsaroucha AK, Asimakopoulos B, Giatromanolaki A, Gavriilidis P, Polychronidis A, Karayiannakis A. (2008)
Total and caspase‑cleaved cytokeratin 18 in chronic cholecystitis: A prospective study.
BMC Gastroenterol. 2008 May 6;8(1):14.
»Abstract
Steele NL, Plumb JA, Vidal L, Tjørnelund J, Knoblauch P, Rasmussen A, Ooi CE, Buhl‑Jensen P, Brown R, Evans TR, DeBono JS. (2008)
A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors.
Clin Cancer Res. 2008 Feb 1;14(3):804‑10.
»Abstract
Volkmann X, Anstaett M, Hadem J, Stiefel P, Bahr MJ, Lehner F, Manns MP, Schulze‑Osthoff K, Bantel H. (2008)
Caspase activation is associated with spontaneous recovery from acute liver failure.
Hepatology. 2008 May;47(5):1624‑33.
»Abstract
Vos MB, Barve S, Joshi-Barve S, Carew JD, Whitington PF, McClain CJ. (2008)
Cytokeratin 18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver disease.
J Pediatr Gastroenterol Nutr. 2008 Oct;47(4):481-5
»Abstract
Wieckowska A, Feldstein AE. (2008)
Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive.
Semin Liver Dis. 2008 Nov;28(4):386-95.
»Abstract
Younossi ZM, Jarrar M, Nugent C, Randhawa M, Afendy M, Stepanova M, Rafiq N, Goodman Z, Chandhoke V, Baranova A. (2008)
A Novel Diagnostic Biomarker Panel for Obesity‑related Nonalcoholic Steatohepatitis (NASH).
Obes Surg. 2008 Nov;18(11):1430-7.
»Abstract
2007
Adlbrecht C, Hoetzenecker K, Posch M, Steiner S, Kopp C, Hacker S, Auer J, Horvath R, Moser B, Roth G, Wolner E, Lang IM, Ankersmit HJ. (2007)
Elevated levels of interleukin‑1beta‑converting enzyme and caspase‑cleaved cytokeratin‑18 in acute myocardial infarction.
Eur J Clin Invest. 2007 May;37(5):372‑80.
»Abstract
Baskin‑Bey ES, Washburn K, Feng S, Oltersdorf T, Shapiro D, Huyghe M, Burgart L, Garrity‑Park M, van Vilsteren FG, Oliver LK, Rosen CB, Gores GJ. (2007)
Clinical Trial of the Pan‑Caspase Inhibitor, IDN‑6556, in Human Liver Preservation Injury.
Am J Transplant. 2007 Jan;7(1):218‑25.
»Abstract
Berndtsson M, Hagg M, Panaretakis T, Havelka AM, Shoshan MC, Linder S. (2007)
Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA.
Int J Cancer. 2007 Jan 1;120(1):175‑80.
»Abstract
Cummings J, Ranson M, Butt F, Moore D, Dive C. (2007)
Qualification of M30 and M65 ELISAs as surrogate biomarkers of cell death: long term antigen stability in cancer patient plasma.
Cancer Chemother Pharmacol. 2007 Nov;60(6):921‑4.
»Abstract
Cummings J, Ward TH, Greystoke A, Ranson M, Dive C. (2007)
Biomarker method validation in anticancer drug development.
Br J Pharmacol. 2007 Sep 17;1‑11
»Abstract
Duan Z, Bradner J, Greenberg E, Mazitschek R, Foster R, Mahoney J, Seiden MV. (2007)
8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells.
Mol Pharmacol. 2007 Nov;72(5):1137-45.
»Abstract
Herrmann R, Fayad W, Schwarz S, Berndtsson M, Linder S. (2007)
Screening for Compounds that Induce Apoptosis of Cancer Cells Grown as Multicellular Spheroids.
J Biomol Screen. 2008 Feb;13(1):1‑8.
»Abstract
Hetz H, Hoetzenecker K, Hacker S, Faybik P, Pollreisz A, Moser B, Roth G, Hoetzenecker W, Lichtenauer M, Klinger M, Krenn CG, Ankersmit HJ. (2007)
Caspase‑cleaved cytokeratin 18 and 20 S proteasome in liver degeneration.
J Clin Lab Anal. 2007;21(5):277‑81.
»Abstract
Jackson CL, Dreaden TM, Theobald LK, Tran NM, Beal TL, Eid M, Gao MY, Shirley RB, Stoffel MT, Vijay Kumar M, Mohnen D. (2007)
Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure.
Glycobiology. 2007 Aug;17(8):805‑19.
»Abstract
Jacob DA, Bahra M, Langrehr JM, Boas‑Knoop S, Stefaniak R, Davis J, Schumacher G, Lippert S, Neumann UP. (2007)
Combination therapy of poly (ADP‑ribose) polymerase inhibitor 3‑aminobenzamide and gemcitabine shows strong antitumor activity in pancreatic cancer cells.
J Gastroenterol Hepatol. 2007 May;22(5):738‑48.
»Abstract
Klenk M, Nakata M, Podbielski A, Skupin B, Schroten H, Kreikemeyer B. (2007)
Streptococcus pyogenes serotype‑dependent and independent changes in infected HEp‑2 epithelial cells.
ISME J. 2007 Dec;1(8):678‑92.
»Abstract
Linder, S. (2007)
Cytokeratin Markers Come of Age.
Tumour Biol. 2007 Aug 23;28(4):189‑195
»Abstract
Luft T, Conzelmann M, Benner A, Rieger M, Hess M, Strohhaecker U, Gorner M, Hegenbart U, Ho AD, Dreger P. (2007)
Serum cytokeratin‑18 fragments as quantitative markers of epithelial apoptosis in liver and intestinal graft‑versus‑host disease.
Blood. 2007 Dec 15;110(13):4535‑42.
»Abstract
Mitry RR, De Bruyne R, Quaglia A, Hughes RD, Dhawan A. (2007)
Noninvasive diagnosis of nonalcoholic fatty liver disease using serum biomarkers.
Hepatology. 2007 Dec;46(6):2047-8
»Abstract
Neuman MG, Benhamou JP, Marcellin P, Valla D, Malkiewicz IM, Katz GG, Trepo C, Bourliere M, Cameron RG, Cohen L, Morgan M, Schmilovitz‑Weiss H, Ben‑Ari Z. (2007)
Cytokine‑chemokine and apoptotic signatures in patients with hepatitis C.
Transl Res. 2007 Mar;149(3):126‑36.
»Abstract
Neuman M, Nicar M. (2007)
Apoptosis in ibuprofen‑induced Stevens‑Johnson syndrome.
Transl Res. 2007 May;149(5):254‑9.
»Abstract
Olofsson MH, Ueno T, Pan Y, Xu R, Cai F, van der Kuip H, Muerdter TE, Sonnenberg M, Aulitzky WE, Schwarz S, Andersson E, Shoshan MC, Havelka AM, Toi M, Linder S. (2007)
Cytokeratin‑18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy.
Clin Cancer Res. 2007 Jun 1;13(11):3198‑206.
»Abstract
Rutherford AE, Hynan LS, Borges CB, Forcione DG, Blackard JT, Lin W, Gorman AR, Shaikh OS, Reuben A, Harrison E, Reddy KR, Le WM, Chung RT; For the alf study group. (2007)
Serum Apoptosis Markers in Acute Liver Failure: A Pilot Study.
Clin Gastroenterol Hepatol. 2007;5:1477‑1483
»Abstract
Tumurbaatar B, Sun Y, Chan T, Sun J. (2007)
Cre‑estrogen receptor‑mediated hepatitis C virus structural protein expression in mice.
J Virol Methods. 2007 Dec;146(1‑2):5‑13.
»Abstract
Ulukaya E, Yilmaztepe A, Akgoz S, Linder S, Karadag M. (2007)
The levels of caspase‑cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival.
Lung Cancer. 2007 Jun;56(3):399‑404.
»Abstract
Wieckowska A, McCullough AJ, Feldstein AE. (2007)
Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future.
Hepatology. 2007 Jul 27;46(2):582‑589
»Abstract
Reply:Wieckowska A, McCullough AJ, Feldstein AE. (2007)
Hepatology. 2007 Nov 28;46(6):2048
»Abstract
Yilmaz Y, Dolar E, Ulukaya E, Akgoz S, Keskin M, Kiyici M, Aker S, Yilmaztepe A, Gurel S, Gulten M, Nak SG. (2007)
Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis.
World J Gastroenterol. 2007 Feb 14;13(6):837‑44.
»Abstract
2006
Cummings J, Ranson M, Lacasse E, Ganganagari JR, St‑Jean M, Jayson G, Durkin J, Dive C. (2006)
Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X‑linked inhibitor of apoptosis protein XIAP.
Br J Cancer. 2006 Jul 3;95(1):42‑8.
»Abstract
Demiray M, Ulukaya EE, Arslan M, Gokgoz S, Saraydaroglu O, Ercan I, Evrensel T, Manavoglu O. (2006)
Response to Neoadjuvant Chemotherapy in Breast Cancer Could be Predictable by Measuring a Novel Serum Apoptosis Product, Caspase‑Cleaved Cytokeratin 18: A Prospective Pilot Study.
Cancer Invest. 2006 Nov;24(7):669‑76.
»Abstract
Duan Z, Bradner JE, Greenberg E, Levine R, Foster R, Mahoney J and Seiden MV. (2006)
SD‑1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.
Clin Cancer Res. 2006 Nov 15;12(22):6844‑52.
»Abstract
Duan Z, Foster R, Bell DA, Mahoney J, Wolak K, Vaidya A, Hampel C, Lee H and Seiden MV. (2006)
Signal transducers and activators of transcription 3 pathway activation in drug‑resistant ovarian cancer.
Clin Cancer Res. 2006 Sep 1;12(17):5055‑63.
»Abstract
Gable KL, Maddux BA, Penaranda C, Zavodovskaya M, Campbell MJ, Lobo M, Robinson L, Schow S, Kerner JA, Goldfine ID, Youngren JF. (2006)
Diarylureas are small‑molecule inhibitors of insulin‑like growth factor I receptor signaling and breast cancer cell growth.
Mol Cancer Ther. 2006 Apr;5(4):1079‑86.
»Abstract
Kaddour‑Djebbar I, Lakshmikanthan V, Shirley RB, Ma Y, Lewis RW, Kumar MV. (2006)
Therapeutic advantage of combining calcium channel blockers and TRAIL in prostate cancer.
Mol Cancer Ther. 2006 Aug;5(8):1958‑66.
»Abstract
Klingstrom J, Hardestam J, Stoltz M, Zuber B, Lundkvist A, Linder S, Ahlm C. (2006)
Loss of cell membrane integrity in puumala hantavirus‑infected patients correlates with levels of epithelial cell apoptosis and perforin.
J Virol. 2006 Aug;80(16):8279‑82.
»Abstract
Kramer, G., Schwartz, S., Hägg, M., Mandic Havelka, A. and Linder, S. (2006)
Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles.
Br J Cancer. 2006 Jun 5;94(11):1592‑8.
»Abstract
Lakshmikanthan V, Kaddour‑Djebbar I, Lewis RW, Kumar MV. (2006)
SAHA‑sensitized prostate cancer cells to TNFalpha‑related apoptosis‑inducing ligand (TRAIL): mechanisms leading to synergistic apoptosis.
Int J Cancer. 2006 Jul 1;119(1):221‑8.
»Abstract
Leuhuber K, Klepal W, Hausott B, Marian B. (2006)
Apoptosis in a tissue‑like culture model of human colorectal adenoma cells.
Tissue Cell. 2006 Jun;38(3):203‑8.
»Abstract
Ma, Y., Lakshmikanthan, V., Lewis, R.W. and Kumar, M.V. (2006)
Sensitization of TRAIL‑restistant cells by inhibition of heat shock protein 90 with low‑dose geldanamycin.
Mol Cancer Ther. 2006 Jan;5(1):170‑8.
»Abstract
Pichon MF, Labroquere M, Rezai K, Lokiec F. (2006)
Variations of soluble fas and cytokeratin 18‑Asp 396 neo‑epitope in different cancers during chemotherapy.
Anticancer Res. 2006 May‑Jun;26(3B):2387‑92.
»Abstract
Shoshan M, Mandic Havelka A, Neumann F and Linder S. (2006)
Sense and sensibility: the use of cell death biomarker assays in high‑throughput anticancer drug screening and monitoring treatment responses.
Expert Opin. Drug Discov. 2006 Nov; Vol. 1, No. 6: 585‑594.
»Abstract
Shukla, S. and Gupta, S. (2006)
Molecular targets for apigenin‑induced cell cycle arrest and apoptosis in prostate cancer cell xenograft.
Mol Cancer Ther. 2006 Apr;5(4):843‑52.
»Abstract
Szerafin T, Horvath A, Moser B, Hacker S, Hoetzenecker K, Steinlechner B, Brunner M, Roth G, Boltz‑Nitulescu G, Peterffy A, Wolner E, Ankersmit HJ. (2006)
Apoptosis‑specific activation markers in on‑ versus off‑pump coronary artery bypass graft (CABG) patients.
Clin Lab. 2006;52(5‑6):255‑61.
»Abstract
Volkmann X, Cornberg M, Wedemeyer H, Lehner F, Manns MP, Schulze‑Osthoff K, Bantel H. (2006)
Caspase activation is required for antiviral treatment response in chronic hepatitis C virus infection.
Hepatology. 2006 Jun;43(6):1311‑6.
»Abstract
Welman A, Cawthorne C, Ponce-Perez L, Barraclough J, Danson S, Murray S, Cummings J, Allen TD, Dive C. (2006)
Increases in c-Src expression level and activity do not promote the growth of human colorectal carcinoma cells in vitro and in vivo.
Neoplasia. 2006 Nov;8(11):905-16.
»Abstract
Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE. (2006)
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease.
Hepatology. 2006 Jul;44(1):27‑33.
»Abstract
2005
Berndtsson M, Konishi Y, Bonni A, Hagg M, Shoshan M, Linder S, Havelka AM. (2005)
Phosphorylation of BAD at Ser‑128 during mitosis and paclitaxel‑induced apoptosis.
FEBS Lett. 2005 Jun 6;579(14):3090‑4.
»Abstract
Cheewatrakoolpong B, Gilchrest H, Anthes JC, Greenfeder S. (2005)
Identification and characterization of splice variants of the human P2X7 ATP channel.
Links Erratum in: Biochem Biophys Res Commun. 2006 Mar 14;342(3):1004.
Biochem Biophys Res Commun. 2005 Jun 24;332(1):17‑27.
»Abstract
Cummings J, Ward TH, Lacasse E, Lefebvre C, St‑Jean M, Durkin J, Ranson M and Dive C. (2005)
Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X‑linked inhibitor of apoptosis protein XIAP.
Br J Cancer. 2005 Feb 14;92(3):532‑8.
»Abstract
Erdal, H., Berndtsson, M., Castro, J., Brunk, U., Shoshan, M.C. and Linder, S. (2005)
Induction of lysosomal membrane permeabilization by compounds that activate p53‑independent apoptosis.
Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):192‑7.
»Abstract
Hostanska K, Nisslein T, Freudenstein J, Reichling J, Saller R. (2005)
Cimicifuga racemosa extract inhibits proliferation of estrogen receptor‑positive and negative human breast carcinoma cell lines by induction of apoptosis.
Breast Cancer Res Treat. 2004 Mar;84(2):151‑60.
»Abstract
Kronenberger B, Wagner M, Herrmann E, Mihm U, Piiper A, Sarrazin C, Zeuzem S. (2005)
Apoptotic cytokeratin 18 neoepitopes in serum of patients with chronic hepatitis C.
J Viral Hepat. 2005 May;12(3):307‑14.
»Abstract
Luciani P, Gelmini S, Ferrante E, Lania A, Benvenuti S, Baglioni S, Mantovani G, Cellai I, Ammannati F, Spada A, Serio M, Peri A. (2005)
Expression of the antiapoptotic gene seladin‑1 and octreotide‑induced apoptosis in growth hormone‑secreting and nonfunctioning pituitary adenomas.
J Clin Endocrinol Metab. 2005 Nov;90(11):6156‑61.
»Abstract
Lövborg, H., Gullbo, J. and Larsson, R (2005)
Screening for apoptosis ‑ classical and emerging techniques (Review paper)
Anticancer Drugs. 2005 Jul;16(6):593‑9.
»Abstract
Seidel N, Volkmann X, Langer F, Flemming P, Manns MP, Schulze‑Osthoff K, Bantel H. (2005)
The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum.
Hepatology. 2005 Jul;42(1):113‑20.
»Abstract
Shirley, B.S., Kaddour‑Djebbar, I., Patel, D.M., Lakshmikanthan, V., Lewis, R.W. and Kumar, M.V. (2005)
Combination of proteasomal inhibitors lactacystin and MG132 induced synergistic apoptosis in prostate cancer cells.
Neoplasia. 2005 Dec;7(12):1104‑11.
»Abstract
2004
Amantana A, London CA, Iversen PL, Devi GR. (2004)
X‑linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells.
Mol Cancer Ther. 2004 Jun;3(6):699‑707.
»Abstract
Bantel H, Lugering A, Heidemann J, Volkmann X, Poremba C, Strassburg CP, Manns MP, Schulze‑Osthoff K. (2004)
Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury.
Hepatology. 2004 Nov;40(5):1078‑87.
»Abstract
Cummings J, Ward TH, Ranson M, Dive C. (2004)
Apoptosis pathway‑targeted drugs ‑ from the bench to the clinic.
Biochim Biophys Acta. 2004 Dec 10;1705(1):53‑66.
»Abstract
Hägg, M., Berndtsson, M., Mandic, A., Zhou, R., Shoshan, M.C., and Linder, S. (2004)
Induction of ER stress by Ellipticine Plant Alkaloids.
Mol Cancer Ther. 2004 Apr;3(4):489‑97.
»Abstract
Kramer, G., Erdal, H., Mertens, H., Nap, M., Mauermann, J., Steiner, G., Marberger, M., Bivén, K., Shoshan, M.C. and Linder, S. (2004)
Differentiation between Cell Death Modes using Measurements of Different Soluble Forms of Extracellular Cytokeratin 18.
Cancer Res. 2004 Mar 1;64(5):1751‑6.
»Abstract
Linder S, Havelka AM, Ueno T, Shoshan MC. (2004)
Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker.
Cancer Lett. 2004 Oct 8;214(1):1‑9.
»Abstract
Loaiza‑Pérez AI, Kenney S, Boswell J, Hollingshead M, Hose C, Linehan WM, Worrell R, Rubinstein L, Sausville EA, Vistica DT. (2004)
Sensitivity of renal cell carcinoma to aminoflavone: role of CYP1A1.
J Urol. 2004 Apr;171(4):1688‑97.
»Abstract
Maheshwari A,Lacson A, Lu W, Fox SE, Barleycorn AA, Christensen RD, Calhoun DA. (2004)
Interleukin‑8/CXCL8 forms an autocrine loop in fetal intestinal mucosa.
Pediatr Res. 2004 Aug;56(2):240‑9. Epub 2004 Jun 4.
»Abstract
Muhl H, Paulukat J, Hofler S, Hellmuth M, Franzen R, Pfeilschifter J. (2004)
The HIV protease inhibitor ritonavir synergizes with butyrate for induction of apoptotic cell death and mediates expression of heme oxygenase‑1 in DLD‑1 colon carcinoma cells.
Br J Pharmacol. 2004 Dec;143(7):890‑8.
»Abstract
Ramskogler K, Brunner M, Hertling I, Dvorak A, Kapusta N, Krenn C, Moser B, Roth G, Lesch OM, Ankersmit HJ, Walter H. (2004)
CDT values are not influenced by epithelial cell apoptosis in chronic alcoholic patients‑preliminary results.
Alcohol Clin Exp Res. 2004 Sep;28(9):1396‑8.
»Abstract
Roth GA, Krenn C, Brunner M, Moser B, Ploder M, Spittler A, Pelinka L, Sautner T, Wolner E, Boltz‑Nitulescu G, Ankersmit HJ. (2004)
Elevated serum levels of epithelial cell apoptosis‑specific cytokeratin 18 in critically ill patients.
Shock. 2004 Sep;22(3):218‑20.
»Abstract
Schutte B, Henfling M, Kolgen W, Bouman M, Meex S, Leers MP, Nap M, Bjorklund V, Bjorklund P, Bjorklund B, Lane EB, Omary MB, Jornvall H, Ramaekers FC. (2004)
Keratin 8/18 breakdown and reorganization during apoptosis.
Exp Cell Res. 2004 Jul 1;297(1):11‑26.
»Abstract
Takada M, Kataoka A, Toi M, Bando H, Toyama K, Horiguchi S, Ueno T, Linder S, Saji S, Hayashi Y, Funata N, Kinoshita J, Murakami S, Ohono S. (2004)
A close association between alteration in growth kinetics by neoadjuvant chemotherapy and survival outcome in primary breast cancer.
Int J Oncol. 2004 Aug;25(2):397‑405.
»Abstract
2003
Bivén, K., Erdal, H., Hägg, M., Ueno, T., Zhou, R., Lynch, M., Rowley, B., Wood, J., Zhang, C., Toi, M., Shoshan, M.C. and Linder, S. (2003)
A novel assay for discovery and characterization of pro‑apoptotic drugs and for monitoring apoptosis in patient sera.
Apoptosis. 2003 Jun;8(3):263‑8.
»Abstract
Maloney EK, McLaughlin JL, Dagdigian NE, Garrett LM, Connors KM, Zhou XM,
Blattler WA, Chittenden T, Singh R. (2003)
An anti‑insulin‑like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation.
Cancer Res. 2003 Aug 15;63(16):5073‑83.
»Abstract
Thurnher, D., Turhani, D., Pelzmann, M., Wannemacher, B., Knerer, B., Formanek, M., Wacheck, V. and Selzer, E. (2003)
Betulinic Acid: A new cytotoxic compound against malignant head & neck cancer cells.
Head Neck. 2003 Sep;25(9):732‑40.
»Abstract
Ueno, T., Toi, M., Bivén, K., Bando, H., Ogawa, T. and Linder, S. (2003)
Measurement of an apoptosis product in the sera of breast cancer patients.
European Journal of Cancer; 2003 Apr;39(6):769‑74.
»Abstract
2001‑2002
Hägg, M., Bivén, K., Ueno, T., Rydlander, L, Björklund, P., Wiman, K.G., Shoshan, M.C. and Linder, S. (2002)
A novel high‑through‑put assay for screening of pro‑apoptotic drugs.
Invest New Drugs. 2002 Aug;20(3):253‑9.
»Abstract
Mandic, A., Viktorsson, K., Molin, M., Akusjärvi, G., Eguchi, H., Hayashi, S.‑I., Toi, M., Hansson, J., Linder, S. and Shoshan, M. (2001)
Cisplatin induces the pro‑apoptotic conformation of Bak in a delta‑MEKK1‑dependent manner.
Mol Cell Biol. 2001 Jun;21(11):3684‑91.
»Abstract
