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M30 Apoptosense® ELISA References

Original Papers

M30 Apoptosense^® assay:
Hägg, M., Bivén, K., Ueno, T., Rydlander, L, Björklund, P., Wiman, K.G., Shoshan, M.C. and Linder, S. (2002)
A novel high‑through‑put assay for screening of pro‑apoptotic drugs.
Invest. New Drugs, 20: 253‑259.
»Abstract

M30-antibody:
Leers, M.P., Kölgen, W., Björklund, V., Bergman, T., Tribbick, G., Persson, B., Björklund, P., Ramaekers, F.C.S., Björklund, B., Nap, M., Jörnvall, H., and Schutte, B. (1999).
Immunocytochemical detection and mapping of a Cytokeratin 18 neo‑epitope exposed during early apoptosis.
J Pathol 187, 567‑572.
»Abstract

REFERENCES IN CHRONOLOGICAL ORDER

(Updated on 25 January 2012)

Year of publication:
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» 2001 – 2002

Antoine DJ, Jenkins RE, Dear JW, Williams DP, McGill MR, Sharpe MR, Craig DG, Simpson KJ, Jaeschke H, Kevin Park B (2012)
Molecular forms of HMGB1 and Keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
J Hepatol 2012, , [Epub ahead of print]
»Abstract

Koo JH, Lee MH, Kim SS, Kim DH, Kim IS, Lee KM, Yoo BM, Lee KJ, Kim JH, Cho SW, Cheong JY (2012)
Changes in serum histologic surrogate markers and procollagen III N-terminal peptide as independent predictors of HBeAg loss in patients with chronic hepatitis B during entecavir therapy.
Clin Biochem. 2012, 45(1-2), 31-6
»Abstract

Moore DJ, Greystoke A, Butt F, Wurthner J, Growcott J, Hughes A, Dive C (2012)
A Pilot Study Assessing the Prognostic Value of CK18 and nDNA Biomarkers in Severe Sepsis Patients
Clin Drug Investig 2012, , [Epub ahead of print]
»Abstract

Alkhouri N, Carter-Kent C, Feldstein AE (2011)
Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
Expert Rev. Gastroenterol. Hepatol. 2011, 5(2), 201–212
»Abstract

Ari F, Napieralski R, Ulukaya E, Dere E, Colling C, Honert K, Krüger A, Kiechle M, Schmitt M (2011)
Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline-based chemotherapy and the demethylating agent decitabine
Cell Biochem Funct 2011, 29(8), 651-9
»Abstract

Arkenau HT, Plummer R, Molife LR, Olmos D, Yap TA, Squires M, Lewis S, Lock V, Yule M, Lyons J, Calvert H, Judson I (2011)
A phase I dose escalation study of AT9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies.
Ann Oncol. 2011, , [Epub ahead of print]
»Abstract

Barut O, Vural P, Sirin S, Aydin S, Dizdar Y (2011)
The oxidant/antioxidant status and cell death mode in oral squamous cell carcinoma
Acta Odontol Scand. 2011, , [Epub ahead of print]
»Abstract

Bilici A, Ustaalioglu BB, Ercan S, Orcun A, Seker M, Salepci T, Gumus M. (2011)
Is there any impact of plasma M30 and M65 levels on progression-free survival of patients with advanced gastric cancer?
Cancer Chemother Pharmacol 2011, 68(2), 309-16
»Abstract

Choudhary V, Kaddour-Djebbar I, Lakshmikanthan V, Ghazaly T, Thangjam GS, Sreekumar A, Lewis RW, Mills IG, Bollag WB, Kumar MV (2011)
Novel role of androgens in mitochondrial fission and apoptosis
Mol Cancer Res. 2011, 9(8), 1067-77
»Abstract

Connoy A, Turner J, Núñez M. (2011)
Levels of Serum Markers of Liver Inflammation and Fibrosis in Patients with Chronic Hepatitis C Virus Infection According to HIV Status and Antiretroviral Use.
AIDS Res Hum Retroviruses. 2011, 27(7), 719-25
»Abstract

Coward J, Kulbe H, Chakravarty P, Leader DA, Vassileva V, Leinster DA, Thompson R, Schioppa T, Nemeth JA, Vermeulin J, Singh N, Avril NE, Cummings J, Rexhepaj E, Jirstrom K, Gallagher WM, Brennan DJ, McNeish IA, Balkwill FR (2011)
Interleukin-6 as a therapeutic target in human ovarian cancer.
Clin Cancer Res. 2011, 17(18), 6083-96
»Abstract

D'Arcy P, Brnjic S, Olofsson MH, Fryknäs M, Lindsten K, De Cesare M, Perego P, Sadeghi B, Hassan M, Larsson R, Linder S (2011)
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
Nat Med. 2011, 17(12), 1636-40
»Abstract

Dasarathy S, Yang Y, McCullough AJ, Marczewski S, Bennett C, Kalhan SC (2011)
Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis
Eur J Gastroenterol Hepatol. 2011, 23(5), 382-8
»Abstract

De Petris L, Brandén E, Herrmann R, Sanchez BC, Koyi H, Linderholm B, Lewensohn R, Linder S, Lehtiö J. (2011)
Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer.
Eur J Cancer. 2011, 47(1), 131-7
»Abstract

Dean EJ, Cummings J, Roulston A, Berger M, Ranson M, Blackhall F, Dive C. (2011)
Optimization of circulating biomarkers of obatoclax-induced cell death in patients with small cell lung cancer.
Neoplasia. 2011 Apr 2011, 13(4), 339-47
»Abstract

Dhandayuthapani S, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, Rathinavelu A (2011)
Bromelain-Induced Apoptosis in GI-101A Breast Cancer Cells
J Med Food 2011, , [Epub ahead of print]
»Abstract

Dowman JK, Tomlinson JW, Newsome PN. (2011)
Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
Aliment Pharmacol Ther. 2011, 33(5), 525-40
»Abstract

Esaki Taito, Takashi Seto, Hiroshi Ariyama, Shuji Arita, Chinatsu Fujimoto, Koichiro Tsukasa, Takuro Kometani, Kaname Nosaki, Fumihiko Hirai, and Katsuro Yagawa (2011)
Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD4877 in Japanese Patients with Solid Tumors
Arch Drug Info 2011, 4(2), 23-31
»Abstract

Farnik H, Lange CM, Hofmann WP, Berger A, Allwinn R, Welker MW, Trojan J, Sarrazin C, Herrmann E, Zeuzem S, Kronenberger B (2011)
Nucleos(t)ide analogue treatment reduces apoptotic activity in patients with chronic hepatitis B.
J Clin Virol. 2011, 52(3), 204-9
»Abstract

Gandhi L, Camidge DR, Ribeiro de Oliveira M, Bonomi P, Gandara D, Khaira D, Hann CL, McKeegan EM, Litvinovich E, Hemken PM, Dive C, Enschede SH, Nolan C, Chiu YL, Busman T, Xiong H, Krivoshik AP, Humerickhouse R, Shapiro GI, Rudin CM. (2011)
Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors.
J Clin Oncol. 2011, 29(7), 909-16
»Abstract

Gieseler RK, Marquitan G, Schlattjan M, Sowa JP, Bechmann LP, Timm J, Roggendorf M, Gerken G, Friedman SL, Canbay A. (2011)
Hepatocyte apoptotic bodies encasing nonstructural HCV proteins amplify hepatic stellate cell activation: implications for chronic hepatitis C.
J Viral Hepat. 2011, 18(11), 760-7
»Abstract

Herzer K, Kneiseler G, Bechmann LP, Post F, Schlattjan M, Sowa JP, Neumann T, Marggraf G, Erbel R, Gerken G, Canbay A, Jochum C. (2011)
Onset of heart failure determines the hepatic cell death pattern.
Ann Hepatol. 2011 Apr 2011, 10(2), 174-9
»Abstract

Janciauskiene S, Wallmark A, Piitulainen E, Köhnlein T, Welte T, Sveger T. (2011)
Performance of enhanced liver fibrosis plasma markers in asymptomatic individuals with ZZ α1-antitrypsin deficiency.
Eur J Gastroenterol Hepatol. 2011, 23(8), 716-20
»Abstract

Jazwinski AB, Thompson AJ, Clark PJ, Naggie S, Tillmann HL, Patel K (2011)
Elevated serum CK18 levels in chronic hepatitis C patients are associated with advanced fibrosis but not steatosis
Journal of Viral Hepatitis 2011, ,

Joka D, Wahl K, Moeller S, Schlue J, Vaske B, Bahr MJ, Manns MP, Schulze-Osthoff K, Bantel H (2011)
Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis.
Hepatology 2011, , [Epub ahead of print]
»Abstract

Kudo C, Yamakoshi H, Sato A, Nanjo H, Ohori H, Ishioka C, Iwabuchi Y, Shibata H (2011)
Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo
BMC Pharmacol. 2011, 11, 4
»Abstract

Kälsch J, Bechmann LP, Kälsch H, Schlattjan M, Erhard J, Gerken G, Canbay A (2011)
Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients
J Nutr Metab. 2011, , 2011:369168
»Abstract

Lavallard VJ, Bonnafous S, Patouraux S, Saint-Paul MC, Rousseau D, Anty R, Le Marchand-Brustel Y, Tran A, Gual P. (2011)
Serum markers of hepatocyte death and apoptosis are non invasive biomarkers of severe fibrosis in patients with alcoholic liver disease.
PLoS One. 2011, 6(3), e17599.
»Abstract

Lebensztejn DM, Wierzbicka A, Socha P, Pronicki M, Skiba E, Werpachowska I, Kaczmarski M (2011)
Cytokeratin-18 and hyaluronic acid levels predict liver fibrosis in children with non-alcoholic fatty liver disease
Acta Biochim Pol 2011, 58(4), 563-6
»Abstract

Luft T, Dietrich S, Falk C, Conzelmann M, Hess M, Benner A, Neumann F, Isermann B, Hegenbart U, Ho AD, Dreger P (2011)
Steroid-refractory GVHD: T-cell attack within a vulnerable endothelial system
Blood 2011, 118(6), 1685-92
»Abstract

Mahadevan D, Plummer R, Squires MS, Rensvold D, Kurtin S, Pretzinger C, Dragovich T, Adams J, Lock V, Smith DM, Von Hoff D, Calvert H (2011)
A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors
Ann Oncol. 2011, 22(9), 2137-43
»Abstract

Mendoza RA, Moody EE, Enriquez MI, Mejia SM, Thordarson G (2011)
Tumorigenicity of MCF-7 human breast cancer cells lacking the p38α mitogen-activated protein kinase
J Endocrinol. 2011, 208(1), 11-9
»Abstract

Mendoza RA, Enriquez MI, Mejia SM, Moody EE, Thordarson G. (2011)
Interactions between IGF-I, estrogen receptor-α (ERα), and ERβ in regulating growth/apoptosis of MCF-7 human breast cancer cells.
J Endocrinol. 2011, 208(1), 40552
»Abstract

Miller MH, Ferguson MA, Dillon JF (2011)
Systematic review of performance of non-invasive biomarkers in the evaluation of non-alcoholic fatty liver disease
Liver Int. 2011, 31(4), 461-73
»Abstract

Musso G, Gambino R, Cassader M, Pagano G (2011)
Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
Ann Med. 2011, 43(8), 617-49
»Abstract

Pan Y, Xu R, Peach M, Huang CP, Branstetter D, Novotny W, Herbst RS, Eckhardt SG, Holland PM (2011)
Evaluation of pharmacodynamic biomarkers in a Phase 1a trial of dulanermin (rhApo2L/TRAIL) in patients with advanced tumours.
Br J Cancer 2011, 105(12), 1830-8
»Abstract

Pandey M, Kaur P, Shukla S, Abbas A, Fu P, Gupta S (2011)
Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study
Mol Carcinog 2011, , [Epub ahead of print]
»Abstract

Ratziu V, Sheikh MY, Sanyal AJ, Lim JK, Conjeevaram H, Chalasani N, Abdelmalek M, Bakken A, Renou C, Palmer M, Levine RA, Bhandari BR, Cornpropst M, Liang W, King B, Mondou E, Rousseau FS, McHutchison J, Chojkier M (2011)
A Phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis.
Hepatology 2011, , [Epub ahead of print]
»Abstract

Richard J, Lingvay I. (2011)
Hepatic steatosis and Type 2 diabetes: current and future treatment considerations.
Expert Rev Cardiovasc Ther. 2011 Mar;9(3):321-8. 2011, 9(3), 321-8
»Abstract

Roth, Diana Lebherz-Eichingera, f, Hendrik Jan Ankersmitb, Stefan Hackerb, Hubert Hetza, f, Thomas Vukovichc, Andrea Pernec, Thomas Reiterd, Alexander Farre, Walter H. Hörld, Martin Haasd and Claus G. Krenn (2011)
Increased total cytokeratin-18 serum and urine levels in chronic kidney disease
Clinica Chimica Acta 2011, 412(9-10), 713-717

Sebens S, Bauer I, Geismann C, Grage-Griebenow E, Ehlers S, Kruse ML, Arlt A, Schäfer H (2011)
Inflammatory macrophages induce Nrf2 transcription factor-dependent proteasome activity in colonic NCM460 cells and thereby confer anti-apoptotic protection
J Biol Chem 2011, 286(47), 40911-21
»Abstract

Shin SJ, ung M, Jeung HC, Kim HR, Rha SY, Roh JK, Chung HC, Ahn JB (2011)
A phase I pharmacokinetic study of TSU-68 (a multiple tyrosine kinase inhibitor of VEGFR-2, FGF and PDFG) in combination with S-1 and oxaliplatin in metastatic colorectal cancer patients previously treated with chemotherapy
Invest New Drugs 2011, , [Epub ahead of print]
»Abstract

Snoeijs MG, van Bijnen A, Swennen E, Haenen GR, Roberts LJ 2nd, Christiaans MH, Peppelenbosch AG, Buurman WA, Ernest van Heurn LW (2011)
Tubular epithelial injury and inflammation after ischemia and reperfusion in human kidney transplantation
Ann Surg 2011, 253(3), 598-604
»Abstract

Tamimi TI, Elgouhari HM, Alkhouri N, Yerian LM, Berk MP, Lopez R, Schauer PR, Zein NN, Feldstein AE. (2011)
An apoptosis panel for nonalcoholic steatohepatitis diagnosis.
J Hepatol. 2011, 54(6), 1224-9.
»Abstract

Ulukaya E, Ari F, Dimas K, Sarimahmut M, Guney E, Sakellaridis N, Yilmaz VT (2011)
Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro
J Cancer Res Clin Oncol. 2011, 137(10), 1425-34
»Abstract

Ulukaya E, Acilan C, Ari F, İkitimur E, Yilmaz Y (2011)
A Glance at the methods for detection of apoptosis qualitatively and quantitatively
Turk J Biochem 2011, 36(3), 261-269

Ulukaya E, Esra Karaagac1, Ferda Ari2, Arzu Y. Oral1, Saduman B. Adim3, Asuman H. Tokullugil1, Türkkan Evrensell (2011)
Chemotherapy increases caspase-cleaved cytokeratin 18 in the serum of breast cancer patients.
Radiology and Oncology 2011, 45(2), 116-122

Wang Y, Zhao Y, Liu Y, Tian L, Jin D (2011)
Chamaejasmine inactivates Akt to trigger apoptosis in human HEp-2 larynx carcinoma cells.
Molecules 2011, 16, 8152-64
»Abstract

Waterhouse M, Samek E, Torres M, Bertz H, Finke J (2011)
Diagnostic utility of a soluble cytokeratin 18 assay for gastrointestinal graft-vs.-host disease detection
Clin Chem Lab Med. 2011, 49(10), 1695-7
»Abstract

Veltkamp C, Anstaett M, Wahl K, Möller S, Gangl S, Bachmann O, Hardtke-Wolenski M, Länger F, Stremmel W, Manns MP, Schulze-Osthoff K, Bantel H (2011)
Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNF{alpha} treatment.
Gut. 2011, 60(10), 1345-53
»Abstract

Yilmaz Y, (2011)
Cytokeratins in hepatitis
Clin Chim Acta 2011, 412(23-24), 2031-6
»Abstract

Anty R, Iannelli A, Patouraux S, Bonnafous S, Lavallard VJ, Senni-Buratti M, Amor IB, Staccini-Myx A, Saint-Paul MC, Berthier F, Huet PM, Le Marchand-Brustel Y, Gugenheim J, Gual P, Tran A. (2010)
A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients.
Aliment Pharmacol Ther. 2010, 32(11-12), 1315-22
»Abstract

Bechmann LP, Jochum C, Kocabayoglu P, Sowa JP, Kassalik M, Gieseler RK, Saner F, Paul A, Trautwein C, Gerken G, Canbay A. (2010)
Cytokeratin 18-based modification of the MELD score improves prediction of spontaneous survival after acute liver injury.
J Hepatol. 2010, 53(4), 639-47
»Abstract

Bechmann LP, Gieseler RK, Sowa JP, Kahraman A, Erhard J, Wedemeyer I, Emons B, Jochum C, Feldkamp T, Gerken G, Canbay A. (2010)
Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis.
Liver Int. 2010, 30(6), 850-9
»Abstract

Bilici A, Ustaalioglu BB, Ercan S, Orcun A, Seker M, Salepci T, Gumus M. (2010)
Is there any impact of plasma M30 and M65 levels on progression-free survival of patients with advanced gastric cancer?
Cancer Chemother Pharmacol 2010, , [Epub ahead of print]
»Abstract

Brandt D, Volkmann X, Anstätt M, Länger F, Manns MP, Schulze-Osthoff K, Bantel H. (2010)
Serum biomarkers of cell death for monitoring therapy response of gastrointestinal carcinomas.
Eur J Cancer. 2010, 46(8), 1464-73
»Abstract

Cave M, Falkner KC, Ray M, Joshi-Barve S, Brock G, Khan R, Bon Homme M, McClain CJ. (2010)
Toxicant-associated steatohepatitis in vinyl chloride workers.
Hepatology. 2010, 51(2), 474-81
»Abstract

Chung WY, Sun JS, Park JH, Lee HL, Lee KS, Kim YS, Sheen SS, Park KJ, Hwang SC, Lee KB, Park KJ. (2010)
Epithelial apoptosis as a clinical marker in idiopathic interstitial pneumonia.
Respiratory Medicine 2010, 104(11), 1722-8
»Abstract

Civera M, Urios A, Garcia-Torres ML, Ortega J, Martinez-Valls J, Cassinello N, del Olmo JA, Ferrandez A, Rodrigo JM, Montoliu C. (2010)
Relationship between insulin resistance, inflammation and liver cell apoptosis in patients with severe obesity.
Diabetes Metab Res Rev. 2010, 26(3), 187-92
»Abstract

Dechêne A, Sowa JP, Gieseler RK, Jochum C, Bechmann LP, El Fouly A, Schlattjan M, Saner F, Baba HA, Paul A, Dries V, Odenthal M, Gerken G, Friedman SL, Canbay A. (2010)
Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation.
Hepatology 2010, 52(3), 1008-16
»Abstract

Dive C, Smith RA, Garner E, Ward T, George-Smith SS, Campbell F, Greenhalf W, Ghaneh P, Neoptolemos JP. (2010)
Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer.
Br J Cancer 2010, 102(3), 577-582
»Abstract

Eren F, Yilmaz Y, Kose S, Ozdemir FT, Yonal O, Kurt R, Ozdogan O, Avsar E. (2010)
Caspase-cleaved fragments of cytokeratin 18 in patients with chronic hepatitis B.
Clin Chim Acta. 2010, 411(23-24), 2029-32
»Abstract

Estep JM, Birerdinc A, Younossi Z. (2010)
Non-invasive diagnostic tests for non-alcoholic fatty liver disease.
Curr Mol Med. 2010, 10(2), 166-172
»Abstract

Feldstein AE, Nobili V. (2010)
Biomarkers in nonalcoholic fatty liver disease: a new era in diagnosis and staging of disease in children.
J Pediatr Gastroenterol Nutr. 2010, 51(4), 378-9
»Abstract

Fitzpatrick E, Mitry RR, Quaglia A, Hussain MJ, DeBruyne R, Dhawan A. (2010)
Serum levels of CK18 M30 and leptin are useful predictors of steatohepatitis and fibrosis in paediatric NAFLD.
J Pediatr Gastroenterol Nutr. 2010, 51(4), 500-6
»Abstract

Gieseler RK, Marquitan G, Schlattjan M, Sowa JP, Bechmann LP, Timm J, Roggendorf M, Gerken G, Friedman SL, Canbay A. (2010)
Hepatocyte apoptotic bodies encasing nonstructural HCV proteins amplify hepatic stellate cell activation: implications for chronic hepatitis C.
J Viral Hepat. 2010, , [Epub ahead of print]
»Abstract

Kahraman A, Schlattjan M, Kocabayoglu P, Yildiz-Meziletoglu S, Schlensak M, Fingas CD, Wedemeyer I, Marquitan G, Gieseler RK, Baba HA, Gerken G, Canbay A. (2010)
Major histocompatibility complex class I-related chains A and B (MIC A/B): a novel role in nonalcoholic steatohepatitis.
Hepatology 2010, 51(1), 92-102
»Abstract

Kaplan-Lefko PJ, Graves JD, Zoog SJ, Pan Y, Wall J, Branstetter DG, Moriguchi J, Coxon A, Huard JN, Xu R, Peach ML, Juan G, Kaufman S, Chen Q, Bianchi A, Kordich JJ, Ma M, Foltz IN, Gliniak BC (2010)
Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types
Cancer Biol Ther. 2010, 9(8), 618-31
»Abstract

Lang L, (2010)
Caspase Activity a Novel Biomarker for NAFLD Severity
2010, , 344

Le Tourneau C, Faivre S, Laurence V, Delbaldo C, Vera K, Girre V, Chiao J, Armour S, Frame S, Green SR, Gianella-Borradori A, Diéras V, Raymond E. (2010)
Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies.
Eur J Cancer 2010, 46(18), 3243-50
»Abstract

Lickliter JD, Francesconi AB, Smith G, Burge M, Coulthard A, Rose S, Griffin M, Milne R, McCarron J, Yeadon T, Wilks A, Cubitt A, Wyld DK, Vasey PA (2010)
Phase I trial of CYT997, a novel cytotoxic and vascular-disrupting agent
Br J Cancer 2010, 103(5), 597-606
»Abstract

Linder S, Olofsson MH, Herrmann R, Ulukaya E. (2010)
Utilization of cytokeratin-based biomarkers for pharmacodynamic studies.
Expert Rev Mol Diagn. 2010, 10(3), 353-9
»Abstract

Papatheodoridis GV, Hadziyannis E, Tsochatzis E, Georgiou A, Kafiri G, Tiniakos DG, Margariti K, Archimandritis AJ. (2010)
Serum apoptotic caspase activity in chronic hepatitis C and nonalcoholic Fatty liver disease.
J Clin Gastroenter 2010, 44(4), e87-95
»Abstract

Paschos KA, Charsou C, Constantinidis TC, Anagnostoulis S, Lambropoulou M, Papachristou F, Simopoulos K, Chatzaki E. (2010)
Corticotropin-releasing hormone receptors mediate opposing effects in cholestasis-induced liver cell apoptosis.
Endocrinology. 2010, 151(4), 1704-12
»Abstract

Pyzlak M, Szewczyk G, Szukiewicz D, Szczesniak A. (2010)
Histamine influence on apoptosis in trophoblast cell cultures.
Inflamm Res. 2010, 59 Suppl 2, S213-5
»Abstract

Samuel D, Ichai P. (2010)
Prognosis indicator in acute liver failure: Is there a place for cell death markers?
J Hepatol. 2010, 53(4), 593-5
»Abstract

Sgier C, Müllhaupt B, Gerlach T, Moradpour D, Negro F, Malé PJ, Heim MH, Malinverni R, Cerny A, Dufour JF. (2010)
Effect of antiviral therapy on circulating cytokeratin-18 fragments in patients with chronic hepatitis C.
J Viral Hepat. 2010, 17(12), 845-50
»Abstract

Tabuchi M, Tomioka K, Kawakami T, Murakami Y, Hiramatsu M, Itoshima T, Sugawara S, Kawashima A, Okita M, Tsukamoto I. (2010)
Serum cytokeratin 18 M30 antigen level and its correlation with nutritional parameters in middle-aged Japanese males with nonalcoholic fatty liver disease (NAFLD).
J Nutr Sci Vitaminol (Tokyo). 2010, 56(5), 271-8.
»Abstract

Tan S, Bechmann LP, Benson S, Dietz T, Eichner S, Hahn S, Janssen OE, Lahner H, Gerken G, Mann K, Canbay A. (2010)
Apoptotic markers indicate nonalcoholic steatohepatitis in polycystic ovary syndrome.
J Clin Endocrinol Metab. 2010, 95(1), 343-8
»Abstract

Tsutsui M, Tanaka N, Kawakubo M, Sheena Y, Horiuchi A, Komatsu M, Nagaya T, Joshita S, Umemura T, Ichijo T, Matsumoto A, Yoshizawa K, Aoyama T, Tanaka E, Sano K. (2010)
Serum fragmented cytokeratin 18 levels reflect the histologic activity score of nonalcoholic fatty liver disease more accurately than serum alanine aminotransferase levels.
J Clin Gastroenterol. 2010, 44(6), 440-7
»Abstract

Ulukaya S, Ulukaya E, Alper I, Yilmaztepe-Oral A, Kilic M. (2010)
Soluble cytokeratin 18 biomarkers may provide information on the type of cell death during early ischemia and reperfusion periods of liver transplantation.
Clin Transplant. 2010, 24(6), 848-54
»Abstract

Valva P, De Matteo E, Galoppo MC, Gismondi MI, Preciado MV. (2010)
Apoptosis markers related to pathogenesis of pediatric chronic hepatitis C virus infection: M30 mirrors the severity of steatosis.
J Med Virol. 2010, 82(6), 949-57
»Abstract

Wong VW, Wong GL, Choi PC, Chan AW, Li MK, Chan HY, Chim AM, Yu J, Sung JJ, Chan HL. (2010)
Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years.
Gut. 2010, 59(7), 969-74
»Abstract

Yaman E, Coskun U, Sancak B, Buyukberber S, Ozturk B, Benekli M. (2010)
Serum M30 levels are associated with survival in advanced gastric carcinoma patients.
Int Immunopharmacol. 2010, 10(7), 719-22
»Abstract

Younossi ZM, Page S, Rafiq N, Birerdinc A, Stepanova M, Hossain N, Afendy A, Younoszai Z, Goodman Z, Baranova A. (2010)
A Biomarker Panel for Non-alcoholic Steatohepatitis (NASH) and NASH-Related Fibrosis.
Obes Surg. 2010, 21(4), 431-9
»Abstract

Zhang L, Kavanagh BD, Thorburn AM, Camidge DR. (2010)
Preclinical and clinical estimates of the basal apoptotic rate of a cancer predict the amount of apoptosis induced by subsequent proapoptotic stimuli.
Clin. Cancer Res. 2010, 16(17), 4478-89
»Abstract

Ausch C, Buxhofer-Ausch V, Olszewski U, Schiessel R, Ogris E, Hinterberger W, Hamilton G (2009)
Circulating Cytokeratin 18 Fragment M65-A Potential Marker of Malignancy in Colorectal Cancer Patients.
J Gastrointest Surg. 2009, 13(11), 43983
»Abstract

Ausch C, Buxhofer-Ausch V, Olszewski U, Hinterberger W, Ogris E, Schiessel R, Hamilton G. (2009)
Caspase-cleaved cytokeratin 18 fragment (M30) as marker of postoperative residual tumor load in colon cancer patients.
Eur J Surg Oncol. 2009, 35(11), 1164-8
»Abstract

Balmer ML, Siegrist K, Zimmermann A, Dufour JF (2009)
Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis.
Liver Int. 2009, 29(8), 1184-8
»Abstract

Bantel H, Schulze-Osthoff K. (2009)
Cell death in sepsis: a matter of how, when, and where.
Crit Care. 2009, 13(4), 173
»Abstract

Been JV, Zimmermann LJ, Debeer A, Kloosterboer N, van Iwaarden JF. (2009)
Bronchoalveolar lavage fluid from preterm infants with chorioamnionitis inhibits alveolar epithelial repair.
Respir Res. 2009, 23;10:116, 23;10:116
»Abstract

Berndtsson M, Beaujouin M, Rickardson L, Havelka AM, Larsson R, Westman J, Liaudet-Coopman E, Linder S (2009)
Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system.
Int J Cancer 2009, 124(6), 1463-9
»Abstract

Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, Mankin H, Hornicek FJ. (2009)
Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines
Mol Cancer Ther. 2009, 8(8), 2122-30
»Abstract

Fayad W, Brnjic S, Berglind D, Blixt S, Shoshan MC, Berndtsson M, Olofsson MH, Linder S. (2009)
Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model.
Int J Cancer. 2009, 125(10), 2450-5
»Abstract

Fayad W, Fryknäs M, Brnjic S, Olofsson MH, Larsson R, Linder S. (2009)
Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.
PLoS One. 2009, 4(10), e7238
»Abstract

Feldstein A, Wickowska A, Lopez AR, Liu YC, Zein NN, McCullough AJ. (2009)
Cytokeratin-18 fragment levels as noninvasive biomarker for nonalcoholic steatohepatitis: A multicenter validation study.
Hepatology 2009, 50(4), 1072-8
»Abstract

Feldstein A, Kleiner D, Kravetz D, Buck M. (2009)
Severe Hepatocellular Injury With Apoptosis Induced by a Hepatitis C Polymerase Inhibitor
J Clin Gastroenterol 2009, 43(4), 1
»Abstract

Fisher MB, Zhang XQ, McConkey DJ, Benedict WF. (2009)
Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon alpha: possible use as a surrogate marker.
Cancer Gene Ther. 2009, 16(7), 567-72
»Abstract

Franzen CA, Chen CC, Todorović V, Juric V, Monzon RI, Lau LF. (2009)
Matrix Protein CCN1 Is Critical for Prostate Carcinoma Cell Proliferation and TRAIL-Induced Apoptosis
Mol Cancer Res 2009, 7(7), 1045-55
»Abstract

Hamad RR, Bremme K, Kallner A, Sten-Linder M (2009)
Increased levels of an apoptotic product in the sera from women with pre-eclampsia.
Scand J Clin Lab Invest. 2009, 15, 39818
»Abstract

Hashimoto E, Farrell GC. (2009)
Will non-invasive markers replace liver biopsy for diagnosing and staging fibrosis in non-alcoholic steatohepatitis?
J Gastroenterol Hepatol 2009, 24(4), 501-3
»Abstract

Hernlund E, Kutuk O, Basaga H, Linder S, Panaretakis T, Shoshan M. (2009)
Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation
Free Radic Biol Med. 2009, 46(12), 1607-13
»Abstract

Hernlund E, Hjerpe E, Avall-Lundqvist E, Shoshan M. (2009)
Ovarian carcinoma cells with low levels of beta-F1-ATPase are sensitive to combined platinum and 2-deoxy-D-glucose treatment.
Mol Cancer Ther. 2009, 8(7), 1916-23
»Abstract

Hofer S, Brenner T, Bopp C, Steppan J, Lichtenstern C, Weitz J, Bruckner T, Martin E, Hoffmann U, Weigand MA (2009)
Cell death serum biomarkers are early predictors for survival in severe septic patients with hepatic dysfunction.
Crit Care. 2009, 13(3), R93
»Abstract

Hou JM, Greystoke A, Lancashire L, Cummings J, Ward T, Board R, Amir E, Hughes S, Krebs M, Hughes A, Ranson M, Lorigan P, Dive C, Blackhall FH. (2009)
Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy.
Am J Pathol. 2009, 175(2), 808-16
»Abstract

Jochum C, Gieseler RK, Gawlista I, Fiedler A, Manka P, Saner FH, Roggendorf M, Gerken G, Canbay A. (2009)
Hepatitis B-associated acute liver failure: immediate treatment with entecavir inhibits hepatitis B virus replication and potentially its sequelae.
Digestion. 2009, 80(4), 235-40
»Abstract

Kieback DG, (2009)
Adenovirus-mediated thymidine kinase gene therapy induces apoptosis in human epithelial ovarian cancer cells and damages PARP-1.
In Vivo. 2009, 23(1), 77-80
»Abstract

Koelink PJ, Lamers CB, Hommes DW, Verspaget HW (2009)
Circulating cell death products predict clinical outcome of colorectal cancer patients.
BMC Cancer 2009, 9, 88
»Abstract

Koelink PJ, Mieremet-Ooms MA, Corver WE, Wolanin K, Hommes DW, Lamers CB, Verspaget HW. (2009)
5-Aminosalicylic Acid Interferes in the Cell Cycle of Colorectal Cancer Cells and Induces Cell Death Modes
Inflamm Bowel Dis 2009, 16(3), 379-89
»Abstract

Koelink PJ, Sier CF, Hommes DW, Lamers CB, Verspaget HW. (2009)
Clinical significance of stromal apoptosis in colorectal cancer.
Br J Cancer 2009, 101(5), 765-73
»Abstract

Koelink PJ, Lamers CB, Hommes DW, Verspaget HW. (2009)
Circulating cell death products predict clinical outcome of colorectal cancer patients.
BMC Cancer. 2009, , 23;9:88
»Abstract

Kutuk O, Arisan ED, Tezil T, Shoshan MC, Basaga H. (2009)
Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation
Carcinogenesis 2009, 30(9), 1517-27
»Abstract

Leal JF, García-Hernández V, Moneo V, Domingo A, Bueren-Calabuig JA, Negri A, Gago F, Guillén-Navarro MJ, Avilés P, Cuevas C, García-Fernández LF, Galmarini CM. (2009)
Molecular pharmacology and antitumor activity of Zalypsis1 in several human cancer cell lines
Biochem Pharmacol 2009, 78(2), 162-70
»Abstract

Linder S, Alaiya A. (2009)
Serum efficacy biomarkers for oncology.
Biomark Med 2009, 3(1), 47-54
»Abstract

Ludmila Vîksna, Jâzeps Keiðs, Artûrs Soèòevs, Baiba Rozentâle, Mâra Pilmane, Natâlija Sevastjanova, Inita Buiíe, Agita Jçruma, Elena Eglîte, Kristîne Âbeltiòa, and Valentîna Sondore (2009)
Novel Laboratory Tests in Assessment of Liver Function in Acute and Chronic Liver Diseases
Proceedings of the Latvian Academy of Sciences 2009, 4(5), 228-233

Malik R, Chang M, Bhaskar K, Nasser I, Curry M, Schuppan D, Byrnes V, Afdhal N. (2009)
The clinical utility of biomarkers and the nonalcoholic steatohepatitis CRN liver biopsy scoring system in patients with nonalcoholic fatty liver disease.
J Gastroenterol Hepatol 2009, 24(4), 564-8
»Abstract

Musso G, Gambino R, Pacini G, De Michieli F, Cassader M. (2009)
Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver.
Am J Clin Nutr. 2009, 89(2), 558-67
»Abstract

Musso G, Gambino R, Pacini G, Pagano G, Durazzo M, Cassader M. (2009)
Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH.
Hepatology. 2009, 49(2), 426-35.
»Abstract

Nilsonne G, Olm E, Szulkin A, Mundt F, Stein A, Kocic B, Rundlöf AK, Fernandes AP, Björnstedt M, Dobra K. (2009)
Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure
J Exp Clin Cancer Res. 2009, 29;28:92, 29;28:92.
»Abstract

Noreen F, Heinrich J, Moelling K. (2009)
Antitumor Activity of Small Double-Stranded Oligodeoxynucleotides Targeting Telomerase RNA in Malignant Melanoma Cells
Oligonucleotides 2009, 19(2), 169-78
»Abstract

Olofsson M H, Cummings J, Fayad W, Brnjic S, Herrmann R, Berndtsson M, Hodgkinson C, Dean E, Odedra R, Wilkinson RW, Mundt KE, Busk M, Dive C, Linder S (2009)
Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker.
Cancer Biomark. 2009, 5(3), 117-25
»Abstract

Ozturk B, Coskun U, Sancak B, Yaman E, Buyukberber S, Benekli M. (2009)
Elevated Serum Levels of M30 and M65 in Patients with Locally Advanced Head and Neck Tumors.
Int Immunopharmacol. 2009, 9(5), 645-8
»Abstract

Pfeifer D, Wallin A, Holmlund B, Sun XF. (2009)
Protein expression following gamma-irradiation relevant to growth arrest and apoptosis in colon cancer cells
J Cancer Res Clin Onco 2009, 135(11), 1583-92
»Abstract

Roehlecke C, Schaller A, Knels L, Funk RH. (2009)
The influence of sublethal blue light exposure on human RPE cells
Mol Vis. 2009, 15, 1929-38
»Abstract

Scott LC, Evans TR, Cassidy J, Harden S, Paul J, Ullah R, O'Brien V, Brown R (2009)
Cytokeratin 18 in plasma of patients with gastrointestinal adenocarcinoma as a biomarker of tumour response.
Br J Cancer 2009, 101(3), 410-7
»Abstract

To the editor: Bantel H, Bahr MJ, Schulze-Osthoff K. (2009)
An apoptosis biomarker for prediction of nonalcoholic steatohepatitis.
Hepatology 2009, 50(3), 991
»Abstract

To the editor: Yilmaz Y, (2009)
Defragmenting the noninvasive diagnosis of nonalcoholic steatohepatitis: Hopes from cytokeratin-18
Hepatology 2009, 50(3), 990-1
»Abstract

Ullen A, Schwarz S, Lennartsson L, Kalkner KM, Sandstrom P, Costa F, Lennernas B, Linder S, Nilsson S. (2009)
Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines.
Scand J Urol Nephrol. 2009, 43(2), 98-103
»Abstract

Wedemeyer I, Bechmann LP, Odenthal M, Jochum C, Marquitan G, Drebber U, Gerken G, Gieseler RK, Dienes HP, Canbay A. (2009)
Adiponectin inhibits steatotic CD95/Fas up-regulation by hepatocytes: Therapeutic implications for hepatitis C.
J Hepatol. 2009, 50(1), 140-9
»Abstract

Yilmaz Y, (2009)
Systematic review: caspase-cleaved fragments of cytokeratin 18 – the promises and challenges of a biomarker for chronic liver disease
Aliment Pharmacol Ther 2009, 30(11-12), 1103-9
»Abstract

Yilmaz Y, Kedrah AE, Ozdogan O. (2009)
Cytokeratin-18 fragments and biomarkers of the metabolic syndrome in nonalcoholic steatohepatitis
World J Gastroenterol 2009, 15(35), 4387-91
»Abstract

Carpinelli P, Moll J. (2008)
Aurora kinase inhibitors: identification and preclinical validation of their biomarkers
Expert Opinion On Therapeutic Targets 2008, 12 (1), 69-80
»Abstract

Cavarretta IT, Neuwirt H, Zaki MH, Steiner H, Hobisch A, Nemeth JA, Culig Z (2008)
Mcl-1 is regulated by IL-6 and mediates the survival activity of the cytokine in a model of late stage prostate carcinoma
Adv Exp Med Biol. 2008, 617, 547-555
»Abstract

Cummings J, Ward TH, Greystoke A, Ranson M, Dive C. (2008)
Biomarker method validation in anticancer drug development.
Br J Pharmacol 2008, 153(4), 646-656
»Abstract

Cummings J, Hodgkinson C, Odedra R, Sini P, Heaton SP, Mundt KE, Ward TH, Wilkinson RW, Growcott J, Hughes A, Dive C. (2008)
Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity.
Mol Cancer Ther. 2008, 7(3), 455-63
»Abstract

de Haas EC, di Pietro A, Simpson KL, Meijer C, Suurmeijer AJ, Lancashire LJ, Cummings J, de Jong S, de Vries EG, Dive C, Gietema JA. (2008)
Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug-sensitive tumor, testicular cancer.
Neoplasia 2008, 10 (10), 1041-8
»Abstract

Diab DL, Yerian L, Schauer P, Kashyap SR, Lopez R, Hazen SL, Feldstein AE. (2008)
Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients.
Clin Gastroenterol Hepatol. 2008, 6(11), 1249-54
»Abstract

Friedman J, Dunn RL, Wood D, Vaishampayan U, Wu A, Bradley D, Montie J, Sarkar FH, Shah RB, Hussain M (2008)
Neoadjuvant docetaxel and capecitabine in patients with high risk prostate cancer
The Journal of Urology 2008, 179 (3), 911-916
»Abstract

Greystoke A, Cummings J, Ward T, Simpson K, Renehan A, Butt F, Moore D, Gietema J, Blackhall F, Ranson M, Hughes A, Dive C. (2008)
Optimisation of circulating biomarkers of cell death for routine clinical use.
Ann Oncol. 2008, 19(5), 990-5
»Abstract

Hernlund E, Ihrlund LS, Khan O, Ates YO, Linder S, Panaretakis T, Shoshan MC. (2008)
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir.
Int J Cancer. 2008, 123(2), 476-83
»Abstract

Herrmann R, Herrmann R, Fayad W, Schwarz S, Berndtsson M, Linder S. (2008)
Screening for Compounds that Induce Apoptosis of Cancer Cells Grown as Multicellular Spheroids
J Biomol Screen 2008, 13(1), 39455
»Abstract

Hu Y, Tan R, MacCalman CD, Eastabrook G, Park SH, Dutz JP, von Dadelszen P. (2008)
IFN-gamma-mediated extravillous trophoblast outgrowth inhibition in first trimester explant culture: a role for insulin-like growth factors
Mol Hum Reprod. 2008, 14 (5), 281-289
»Abstract

Krysko DV, Vanden Berghe T, D'Herde K, Vandenabeele P. (2008)
Apoptosis and necrosis: detection, discrimination and phagocytosis.
Methods. 2008, 44 (3), 205-221
»Abstract

Lee KS, Choi YH, Kim YS, Baik SH, Oh YJ, Sheen SS, Park JH, Hwang SC, Park KJ. (2008)
Evaluation of bronchoalveolar lavage fluid from ARDS patients with regard to apoptosis.
Respiratory Medicine 2008, 102 (3), 464-469
»Abstract

Micha D, Cummings J, Shoemaker A, Elmore S, Foster K, Greaves M, Ward T, Rosenberg S, Dive C, Simpson K. (2008)
Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer.
Clin Cancer Res. 2008, 14(22), 7304-7310
»Abstract

Papatheodoridis GV, Hadizyannis E, Tsochatzis E, Chrysanthos N, Georgiou A, Kafiri G, Manolakopoulos S, Tiniakos DG, Giannousis I, Manesis E, Archimandritis AJ. (2008)
Serum Apoptotic Caspase Activity As A Marker Of Severity In Hbeag‑Negative Chronic Hepatitis B Virus Infection
Gut. 2008, 57 (4), 500-6
»Abstract

Steele NL, Plumb JA, Vidal L, Tjørnelund J, Knoblauch P, Rasmussen A, Ooi CE, Buhl-Jensen P, Brown R, Evans TR, DeBono JS (2008)
A phase 1 pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors.
Clin Cancer Res 2008, 14(3), 804-810
»Abstract

Strandberg Ihrlund L, Hernlund E, Khan O, Shoshan CM (2008)
3-Bromopyruvate as inhibitor of tumor cell energy metabolism and chemopotentiator of platinum drugs.
Molecular Oncology 2008, 2, 94-101
»Abstract

Wieckowska A, Feldstein AE. (2008)
Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive.
Semin Liver Dis. 2008, 28(4), 386-95
»Abstract

Volkmann X, Anstaett, M., Hadem, J., Stiefel, P., Bahr, M J., Frank, L., Manns, M P., Schulze-Osthoff, K., Bantel, H. (2008)
Caspase activation is associated with spontaneous recovery from acute liver failure.
Hepatology 2008, 22237, 1624-1633
»Abstract

Vos MB, Barve S, Joshi-Barve S, Carew JD, Whitington PF, McClain CJ. (2008)
Cytokeratin 18, a marker of cell death, is increased in children with suspected nonalcoholic fatty liver disease.
J Pediatr Gastroenterol Nutr 2008, 47(4), 481-5
»Abstract

Younossi ZM, (2008)
Review article: current management of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
Aliment Pharmacol Ther. 2008, 28(1), 2-12
»Abstract

Younossi ZM, Jarrar M, Nugent C, Randhawa M, Afendy M, Stepanova M, Rafiq N, Goodman Z, Chandhoke V, Baranova A. (2008)
A Novel Diagnostic Biomarker Panel for Obesity-related Nonalcoholic Steatohepatitis (NASH).
Obes Surg 2008, ,
»Abstract

Adlbrecht C, Hoetzenecker K, Posch M, Steiner S, Kopp C, Hacker S, Auer J, Horvath R, Moser B, Roth G, Wolner E, Lang IM, Ankersmit HJ (2007)
Elevated levels of interleukin-1beta-converting enzyme and caspase-cleaved cytokeratin-18 in acute myocardial infarction.
Eur J Clin Invest 2007, 37(5), 372-80
»Abstract

Baskin-Bey E S, Washburn K, Feng S, Oltersdorf T, Shapiro D, Huyghe M, Burgart L, Garrity-Park M, van Vilsteren FG, Oliver LK, Rosen CB, Gores GJ (2007)
Clinical Trial of the Pan-Caspase Inhibitor, IDN-6556, in Human Liver Preservation Injury
Am J Transplant 2007, 7(1), 218-25
»Abstract

Bechmann L P, Guido Marquitan, Christoph Jochum, Fuat Saner, Guido Gerken, Ali Canbay (2007) (2007)
Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute‑on‑chronic liver failure
Liver International 2007, 2007, 1478-3231
»Abstract

Berndtsson M, Hagg M, Panaretakis T, Havelka AM, Shoshan MC, Linder S (2007)
Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA.
Int J Cancer 2007, 120(1), 175-80
»Abstract

Cavarretta IT, Neuwirt H, Untergasser G, Moser PL, Zaki MH, Steiner H, Rumpold H, Fuchs D, Hobisch A, Nemeth JA, Culig Z. (2007)
The antiapoptotic effect of IL-6 autocrine loop in a cellular model of advanced prostate cancer is mediated by Mcl-1.
Oncogene. 2007, 26(20), 2822-32
»Abstract

Cummings J, Ranson M, Butt F, Moore D, Dive C (2007)
Qualification of M30 and M65 ELISAs as surrogate biomarkers of cell death: long term antigen stability in cancer patient plasma.
Cancer Chemother Pharmacol 2007, , 921-4
»Abstract

Duan Z, Bradner J, Greenberg E, Mazitschek R, Foster R, Mahoney J, Seiden MV. (2007)
8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells.
Mol Pharmacol 2007, 72(5), 1137-45
»Abstract

Hetz H, Hoetzenecker K, Hacker S, Faybik P, Pollreisz A, Moser B, Roth G, Hoetzenecker W, Lichtenauer M, Klinger M, Krenn CG, Ankersmit HJ (2007)
Caspase-cleaved cytokeratin 18 and 20 S proteasome in liver degeneration.
J Clin Lab Anal 2007, 21(5), 277-81
»Abstract

Jackson C L, Dreaden TM, Theobald LK, Tran NM, Beal TL, Eid M, Gao MY, Shirley RB, Stoffel MT, Vijay Kumar M, Mohnen D. (2007)
Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure.
Glycobiology 2007, ,
»Abstract

Jacob D A, Bahra M, Langrehr JM, Boas-Knoop S, Stefaniak R, Davis J, Schumacher G, Lippert S, Neumann UP (2007)
Combination therapy of poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide and gemcitabine shows strong antitumor activity in pancreatic cancer cells.
J Gastroenterol Hepatol 2007, 22(5), 738-48
»Abstract

Klenk M, Nakata M, Podbielski A, Skupin B, Schroten H, Kreikemeyer B. (2007)
Streptococcus pyogenes serotype-dependent and independent changes in infected HEp-2 epithelial cells
ISME J. 2007, 1:8, 678-92
»Abstract

Linder S, (2007)
Cytokeratin Markers Come of Age
Tumour Biol 2007, 28(4), 189-195
»Abstract

Luft T, Conzelmann M, Benner A, Rieger M, Hess M, Strohhaecker U, Gorner M, Hegenbart U, Ho AD, Dreger P. (2007)
Serum cytokeratin-18 fragments as quantitative markers of epithelial apoptosis in liver and intestinal graft versus host disease.
Blood 2007, 110(13), 4535-42
»Abstract

Neuman M, Nicar M (2007)
Apoptosis in ibuprofen-induced Stevens-Johnson syndrome
Transl Res. 2007, 149(5), 254-9
»Abstract

Neuman M, Benhamou JP, Marcellin P, Valla D, Malkiewicz IM, Katz GG, Trepo C, Bourliere M, Cameron RG, Cohen L, Morgan M, Schmilovitz-Weiss H, Ben-Ari Z. (2007)
Cytokine – chemokine and apoptotic signatures in patients with hepatitis C.
Transl Res. 2007, 149(3), 126-36
»Abstract

Olofsson M H, Ueno T, Pan Y, Xu R, Cai F, van der Kuip H, Muerdter TE, Sonnenberg M, Aulitzky WE, Schwarz S, Andersson E, Shoshan MC, Havelka AM, Toi M, Linder S. (2007)
Cytokeratin 18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy
Clin Cancer Res 2007, 13(11), 3198-3206 
»Abstract

Rutherford AE, Hynan LS, Borges CB, Forcione DG, Blackard JT, Lin W, Gorman AR, Shaikh OS, Reuben A, Harrison E, Reddy KR, Le WM, Chung RT (2007)
Serum apoptosis markers in acute liver failure: a pilot study.
Clin Gastroenterol Hepatol. 2007, 5(12), 1477-83
»Abstract

Tumurbaatar B, Sun Y, Chan T, Sun J. (2007)
Cre-estrogen receptor-mediated hepatitis C virus structural protein expression in mice
J Virol Methods 2007, 146 (1-2), 5-13
»Abstract

Ulukaya E, Yilmaztepe A, Akgoz S, Linder S, Karadag M (2007)
The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival
Lung Cancer 2007, 56(3), 399-404
»Abstract

Wieckowska A, McCullough AJ, Feldstein AE (2007)
Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future.
Hepatology 2007, 46(2), 582-589
»Abstract

Voorzanger-Rousselot N, Garnero P (2007)
Biochemical markers in oncology. Part I: molecular basis. Part II: clinical uses
Cancer Treat Rev. 2007, 33 (3), 230-283
»Abstract

Yagmur E, Trautwein C, Leers MP, Gressner AM, Tacke F (2007)
Elevated apoptosis-associated cytokeratin 18 fragments (CK18Asp386) in serum of patients with chronic liver diseases indicate hepatic and biliary inflammation
Clin Biochem 2007, 40(9-10), 651-5
»Abstract

Yilmaz Y, Dolar E, Ulukaya E, Akgoz S, Keskin M, Kiyici M, Aker S, Yilmaztepe A, Gurel S, Gulten M, Nak SG. (2007)
Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis.
World J Gastroenterol 2007, 13(6), 837-44
»Abstract

Cummings J, Ranson M, Lacasse E, Ganganagari JR, St-Jean M, Jayson G, Durkin J, Dive C.. (2006)
Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP
Br J Cancer 2006, 95, 42-48
»Abstract

Demiray M , Ulukaya EE, Arslan M, Gokgoz S, Saraydaroglu O, Ercan I, Evrensel T, Manavoglu O. (2006)
Response to Neoadjuvant Chemotherapy in Breast Cancer Could be Predictable by Measuring a Novel Serum Apoptosis Product, Caspase-Cleaved Cytokeratin 18: A Prospective Pilot Study.
Cancer Invest 2006, 24(7), 669-76
»Abstract

Duan Z, Bradner JE, Greenberg E, Levine R, Foster R, Mahoney J and Seiden MV (2006)
SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.
Clin Cancer Res 2006, 12(22) , 6844-52
»Abstract

Duan Z, Foster R, Bell DA, Mahoney J, Wolak K, Vaidya A, Hampel C, Lee H and Seiden MV. (2006)
Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer.
Clin Cancer Res 2006, 12(17), 5055-63
»Abstract

Gable KL, Maddux BA, Penaranda C, Zavodovskaya M, Campbell MJ, Lobo M, Robinson L, Schow S, Kerner JA, Goldfine ID, Youngren JF (2006)
Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.
Mol Cancer Ther 2006, 5(4), 1079-86
»Abstract

Kaddour-Djebbar I, Lakshmikanthan V, Shirley RB, Ma Y, Lewis RW, Kumar MV (2006)
Therapeutic advantage of combining calcium channel blockers and TRAIL in prostate cancer.
Mol Cancer Ther 2006, 5(8), 1958-66
»Abstract

Klingstrom J, Hardestam J, Stoltz M, Zuber B, Lundkvist A, Linder S, Ahlm C (2006)
Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin.
J Virol 2006, 80(16), 8279-82
»Abstract

Kramer G, Schwartz, S., Hägg, M., Mandic Havelka, A. and Linder, S (2006)
Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles.
Br J Cancer 2006, 94(11), 1592-8
»Abstract

Lakshmikanthan V, Kaddour-Djebbar I, Lewis RW, Kumar MV (2006)
SAHA-sensitized prostate cancer cells to TNFalpha-related apoptosis-inducing ligand (TRAIL): mechanisms leading to synergistic apoptosis.
Int J Cancer 2006, 119, 221-8
»Abstract

Leuhuber K, Klepal W, Hausott B, Marian B. (2006)
Apoptosis in a tissue-like culture model of human colorectal adenoma cells.
Tissue Cell. 2006, 38(3), 203-8
»Abstract

Ma Y, Lakshmikanthan, V., Lewis, R.W. and Kumar, M.V (2006)
Sensitization of TRAIL-restistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin.
Mol Cancer Ther 2006, 5(1) , 170-178
»Abstract

Pichon M F, Labroquere M, Rezai K, Lokiec F. (2006)
Variations of soluble fas and cytokeratin 18-Asp 396 neo-epitope in different cancers during chemotherapy
Anticancer Res 2006, 26(3B), 2387-92
»Abstract

Shoshan M, Mandic Havelka A, Neumann F and Linder S (2006)
Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses.
Expert Opin. Drug Discov 2006, Vol. 1 No. 6, 585-594

Shukla S, Gupta, S. (2006)
Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft.
Mol Cancer Ther 2006, 5(4) , 843-852
»Abstract

Szerafin T, Horvath A, Moser B, Hacker S, Hoetzenecker K, Steinlechner B, Brunner M, Roth G, Boltz-Nitulescu G, Peterffy A, Wolner E, Ankersmit HJ (2006)
Apoptosis-specific activation markers in on- versus off-pump coronary artery bypass graft (CABG) patients
Clin Lab 2006, 52(5-6), 255-61
»Abstract

Welman A, Cawthorne C, Ponce-Perez L, Barraclough J, Danson S, Murray S, Cummings J, Allen TD, Dive C. (2006)
Increases in c-Src expression level and activity do not promote the growth of human colorectal carcinoma cells in vitro and in vivo.
Neoplasia 2006, 8(11), 906-16
»Abstract

Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE (2006)
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
Hepatology 2006, 44(1), 27-33
»Abstract

Volkmann X, Cornberg M, Wedemeyer H, Lehner F, Manns MP, Schulze-Osthoff K, Bantel H. (2006) (2006)
Caspase activation is required for antiviral treatment response in chronic hepatitis C virus infection.
Hepatology 2006, 43(6), 1311-1316
»Abstract

Berndtsson M, Konishi Y, Bonni A, Hagg M, Shoshan M, Linder S, Havelka AM (2005)
Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis.
FEBS Lett 2005, 579(14) , 3090-3094
»Abstract

Cheewatrakoolpong B, Gilchrest H, Anthes JC, Greenfeder S. (2005)
Identification and characterization of splice variants of the human P2X7 ATP channel
Biochem Biophys Res Commun 2005, 342(3), 1004
»Abstract

Cummings J, Ward TH, Lacasse E, Lefebvre C, St-Jean M, Durkin J, Ranson M and Dive C. (2005)
Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.
Br J Cancer 2005, 92, 532-538
»Abstract

Erdal H, Berndtsson, M., Castro, J., Brunk, U., Shoshan, M.C. and Linder, S (2005)
Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis.
Proc. Natl. Acad. Sci. USA 2005, 102, 192-197
»Abstract

Kronenberger B, Wagner M, Herrmann E, Mihm U, Piiper A, Sarrazin C, Zeuzem S. (2005)
Apoptotic cytokeratin 18 neoepitopes in serum of patients with chronic hepatitis C.
J Viral Hepat. 2005, 12(3), 307-14
»Abstract

Luciani P, Gelmini, S., Ferrante, E., Lania, A., Benvenuti, B., Baglioni, S., Mantovani, G., Cellai, I., Ammannati, F., Spada, A., Serio, M., Peri, A. (2005)
Expression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas
Jourlan of Clinical Endocrinology & Metabolism 2005, 11, 6156-6161
»Abstract

Lövborg H, Gullbo, J. and Larsson, R (2005)
Screening for apoptosis - classical and emerging techniques
Anticancer Drugs 2005, 16(6), 593-599
»Abstract

Seidel N, Volkmann X, Langer F, Flemming P, Manns MP, Schulze-Osthoff K, Bantel H. (2005)
The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum
Hepatology 2005, 42, 113-120
»Abstract

Shirley B S, Kaddour-Djebbar, I., Patel, D.M., Lakshmikanthan, V., Lewis, R.W. and Kumar, M.V. (2005)
Combination of proteasomal inhibitors lactacystin and MG132 induced synergistic apoptosis in prostate cancer cells.
Neoplasia 2005, 7(12) , 1104-1111
»Abstract

Ueno T, Toi, M. and Linder, S (2005)
Detection of epithelial cell death in the body by cytokeatin 18 measurement.
Biomed&Pharmacotherapy 2005, , 359-362
»Abstract

Amantana A, London CA, Iversen PL, Devi GR. (2004)
X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells.
Mol Cancer Ther. 2004, 3(6), 699-707
»Abstract

Bantel H, Lugering A, Heidemann J, Volkmann X, Poremba C, Strassburg CP, Manns MP, Schulze‑Osthoff K. (2004)
Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury.
Hepatology 2004, 40, 1078-1087
»Abstract

Cummings J, Ward TH, Ranson M, Dive C. (2004)
Apoptosis pathway-targeted drugs - from the bench to the clinic.
Biochim Biophys Acta 2004, 1705(1), 53-66
»Abstract

Hostanska K, Nisslein T, Freudenstein J, Reichling J, Saller R. (2004)
Cimicifuga racemosa extract inhibits proliferation of estrogen
Breast Cancer Res Treat. 2004, 84(2), 151-60
»Abstract

Hägg M, Berndtsson, M., Mandic, A., Zhou, R., Shoshan, M.C., and Linder, S (2004)
Induction of ER stress by Ellipticine Plant Alkaloids.
Molecular Cancer Therapeutics 2004, 3, 489-497
»Abstract

Kramer G, Erdal, H., Mertens, H., Nap, M., Mauermann, J., Steiner, G., Marberger, M., Bivén, K., Shoshan, M.C. and Linder, S. (2004)
Differentiation between Cell Death Modes using Measurements of Different Soluble Forms of Extracellular Cytokeratin 18.
Cancer Research 2004, 64, 1751-1756
»Abstract

Linder S, Havelka AM, Ueno T, Shoshan MC (2004)
Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker.
Cancer Lett. 2004, 214,
»Abstract

Loaiza-Pérez A I, Kenney S, Boswell J, Hollingshead M, Hose C, Linehan WM, Worrell R, Rubinstein L, Sausville EA, Vistica DT. (2004)
Sensitivity of renal cell carcinoma to aminoflavone: role of CYP1A1.
Journal of Urology 2004, 171, 1688-1697
»Abstract

Maheshwari A, Lacson A, Lu W, Fox SE, Barleycorn AA, Christensen RD, Calhoun DA. (2004)
Interleukin-8/CXCL8 forms an autocrine loop in fetal intestinal mucosa.
Pediatric Res 2004, 56, 240-9
»Abstract

Muhl H, Paulukat J, Hofler S, Hellmuth M, Franzen R, Pfeilschifter J (2004)
The HIV protease inhibitor ritonavir synergizes with butyrate for induction of apoptotic cell death and mediates expression of heme oxygenase-1 in DLD-1 colon carcinoma cells.
Br J Pharmacol 2004, 143, 890-8
»Abstract

Ramskogler K, Brunner M, Hertling I, Dvorak A, Kapusta N, Krenn C, Moser B, Roth G, Lesch OM, Ankersmit HJ, Walter H. (2004)
CDT values are not influenced by epithelial cell apoptosis in chronic alcoholic patients-preliminary results.
Alcohol Clin Exp Res. 2004, 28(9), 1396-8
»Abstract

Roth G A, Krenn C, Brunner M, Moser B, Ploder M, Spittler A, Pelinka L, Sautner T, Wolner E, Boltz‑Nitulescu G, Ankersmit HJ. (2004)
Elevated serum levels of epithelial cell apoptosis-specific cytokeratin 18 in critically ill patients
Shock 2004, 22, 218-20
»Abstract

Schutte B, Henfling M, Kolgen W, Bouman M, Meex S, Leers MP, Nap M, Bjorklund V, Bjorklund P, Bjorklund B, Lane EB, Omary MB, Jornvall H, Ramaekers FC. (2004)
Keratin 8/18 breakdown and reorganization during apoptosis.
Exp Cell Res 2004, 297, 39412
»Abstract

Takada M, Kataoka A, Toi M, Bando H, Toyama K, Horiguchi S, Ueno T, Linder (2004)
A close association between alteration in growth kinetics by neoadjuvant
Int J Oncol. 2004, 25(2), 397-405
»Abstract